지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Translationally controlled tumor protein (TCTP) activates basophils to release histamine and causes chronic inflammation. It was also reported that TCTP significantly reduced in brain of Alzheimer's Disease and Down Syndrome as compared to normal person, suggesting that TCTP might be involved in cognitive function. We wondered whether TCTP could act as a general inducer in neurotransmitters release in brain. We, therefore, investigated the role of TCTP in PC12 cell line which expressed neuronal properties. We found that TCTP could activate JNK, and the activity was inhibited by pretreatment of dicoumarol, a JNK inhibitor. However, TCTP could not activate ERK that has known to be involved in neurotransmitter release. These suggest TCTP did not participate in neurotransmitter release from PC12 cells, and TCTP might not be a general inducer in neurotransmitter release.
목차
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참고문헌 (22)
참고문헌 신청
Warner, J. A / 1986 / Identification of histamine releasing factor(s) in the late phase of cutaneous IgE-mediated reactions / J. Immunol 136:2583
Yoneda, K / 2004 / Stimulation of human bronchial epithelial cells by IgE-dependent histamine-releasing factor / Am. J. Physiol. Lung Cell Mol. Physiol 286:174
MacDonald, S. M / 1995 / Molecular identification of an IgE-dependent histaminereleasing factor / Science 269:688
Thueson, D. O / 1979 / Histamine-releasing activity (HRA). I. Production by mitogen- or antigen-stimulated human mononuclear cells / J.Immunol 123:626
Sanchez, J. C / 1997 / Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes / Electrophoresis 18:150
Yoneda, K / 2004 / Stimulation of human bronchial epithelial cells by IgE-dependent histamine-releasing factor / Am. J. Physiol. Lung Cell Mol. Physiol 286:174
MacDonald, S. M / 1995 / Molecular identification of an IgE-dependent histaminereleasing factor / Science 269:688
Thueson, D. O / 1979 / Histamine-releasing activity (HRA). I. Production by mitogen- or antigen-stimulated human mononuclear cells / J.Immunol 123:626
Sanchez, J. C / 1997 / Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes / Electrophoresis 18:150
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