지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.6
- 수록면
- 71 - 81 (11page)
이용수
초록· 키워드
오류제보하기
Translationally controlled tumor protein (TCTP) is also known as histamine releasing factor as it has the ability to activate mast cells. To investigate the role of TCTP in the pathogenesis of chronic spontaneous urticaria (CSU), we evaluated serum level of TCTP and effect of TCTP on basophil and mast cell degranulation. TCTP levels in the sera from 116 CSU patients and 70 normal healthy controls (NCs) were measured by ELISA. CD203c expression on basophils from CSU patients and β-hexosaminidase release from Laboratory of Allergic Disease 2 mast cells were measured upon stimulation monomeric and dimeric TCTP. Nonreducing Western blot analysis was used for detecting dimeric TCTP. No difference was observed in serum TCTP levels between CSU patients and NCs (p=0.676). However, dimeric TCTP intensity on Western blot was stronger in CSU patients than in NCs. TCTP levels were higher in patients with severe CSU (p=0.049) and with IgG positivity to FcɛRIα (p=0.038). A significant positive correlation was observed between TCTP and eosinophil cationic protein levels (Spearman’s rho=0.341; p=0.001). Both basophil and mast cell degranulation were significantly increased after stimulation with dimeric TCTP, but not with monomic TCTP. The ability of TCTP to activate basophil and mast cells is dependent on dimerization, suggesting that the inhibition of TCTP dimerization can be a therapeutic option for CSU. Association between TCTP levels and the presence of IgG to high affinity Fc epsilon receptor I alpha subunit in CSU patients indicates that autoimmune mechanisms may be involved in the dimerization of TCTP.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (35)
참고문헌 신청
Zuberbier T / 2018 / The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria / Allergy 73:1393~1414
Sánchez-Borges M / 2012 / Diagnosis and treatment of urticaria and angioedema: a worldwide perspective / World Allergy Organ J 5:125~147
이나미 / 2017 / Epidemiology of Chronic Urticaria in Korea Using the Korean Health Insurance Database, 2010-2014 / Allergy, Asthma & Immunology Research 9(5):438~445
MacDonald SM / 2012 / Potential role of histamine releasing factor (HRF) as a therapeutic target for treating asthma and allergy / J Asthma Allergy 5:51~59
Xu A / 1999 / Expression of translationally controlled tumour protein is regulated by calcium at both the transcriptional and post-transcriptional level / Biochem J 342:683~689
Sánchez-Borges M / 2012 / Diagnosis and treatment of urticaria and angioedema: a worldwide perspective / World Allergy Organ J 5:125~147
이나미 / 2017 / Epidemiology of Chronic Urticaria in Korea Using the Korean Health Insurance Database, 2010-2014 / Allergy, Asthma & Immunology Research 9(5):438~445
MacDonald SM / 2012 / Potential role of histamine releasing factor (HRF) as a therapeutic target for treating asthma and allergy / J Asthma Allergy 5:51~59
Xu A / 1999 / Expression of translationally controlled tumour protein is regulated by calcium at both the transcriptional and post-transcriptional level / Biochem J 342:683~689
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UCI(KEPA) : I410-ECN-0101-2019-517-000788628