지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제29권 제1호
- 발행연도
- 2006.1
- 수록면
- 50 - 58 (9page)
이용수
초록· 키워드
오류제보하기
Translationally controlled tumor protein (TCTP), also known as histamine releasing factor (HRF), is found abundantly in different eukaryotic cell types. The sequence homology of TCTP between different species is very high, belonging to the MSS4/DSS4 superfamily of proteins. TCTP is involved in both cell growth and human late allergy reaction, as well as having a calcium binding property; however, its primary biological functions remain to be clearly elucidated. In regard to many possible functions, the TCTP of Plasmodium falciparum (Pf) is known to bind with an antimalarial agent, artemisinin, which is activated by heme. It is assumed that the endoperoxide-bridge of artemisinin is opened up by heme to form a free radical, which then eventually alkylates, probably to the Cys14 of PfTCTP. Study of the docking of artemisinin with heme, and subsequently with PfTCTP, was carried out to verify the above hypothesis on the basis of structural interactions. The three dimensional (3D) structure of PfTCTP was built by homology modeling, using the NMR structure of the TCTP of Schizosaccharomyces pombe as a template. The quality of the model was examined based on its secondary structure and biological function, as well as with the use of structure evaluating programs. The interactions between artemisinin, heme and PfTCTP were then studied using the docking program, FlexiDock. The center of the peroxide bond of artemisinin and the Fe of heme were docked within a short distance of $2.6{\AA}$, implying the strong possibility of an interaction between the two molecules, as proposed. When the activated form of artemisinin was docked on the PfTCTP, the C4-radical of the drug faced towards the sulfur of Cys14 within a distance of $2.48{\AA}$, again suggesting the possibility of alkylation having occurred. These results confirm the proposed mechanism of the antimalarial effect of artemisinin, which will provide a reliable method for establishing the mechanism of its biological activity using a molecular modeling study.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Binding modes of artemisinin to malarial TCTP demonstrated by computer modeling
대한약학회 학술대회
2002 .01
-
Antimalarial Activity of C-10 Substituted Triazolyl Artemisinin
Parasites, Hosts and Diseases
2017 .12
-
Homology modeling of human TCTP using three different computer programs
대한약학회 학술대회
2001 .01
-
PC12 세포주에서 Translationally Controlled Tumor Protein에 의한 Mitogen-activated Protein Kinases 활성 조절
약학회지
2010 .01
-
Identification of the Calcium Binding Sites in Translationally Controlled Tumor Protein
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2000 .01
-
Dimerized, Not Monomeric, Translationally Controlled Tumor Protein Induces Basophil Activation and Mast Cell Degranulation in Chronic Urticaria
Immune Network
2019 .06
-
Docking of Retinol into the 3D Structural Model of Human TCTP Constructed by Homology Modeling
대한약학회 학술대회
2003 .01
-
The effect of artemisinin on the rabbit IgG accelerated nephrotoxic serum glomerulonephritis in mice
논문집 : 대전대학교 한의학연구소. 한의학편
1996 .01
-
Suppressor of Variegation 3-9 Homolog 2, a Novel Binding Protein of Translationally Controlled Tumor Protein, Regulates Cancer Cell Proliferation
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Targeted Efficacy of Dihydroartemisinin for Translationally Controlled Protein Expression in a Lung Cancer Model
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Molecular Cloning of a Partial Cadinane Synthase Gene from Artemisia annua
한국응용약물학회 추계학술발표논문집
1998 .01
-
Plasmodium falciparum Genotype Diversity in Artemisinin Derivatives Treatment Failure Patients along the Thai-Myanmar Border
Parasites, Hosts and Diseases
2014 .12
-
Amorpha-4,11-diene Synthase of Artemisia annua: cDNA Isolation and Bacterial Expression of a Terpene Synthase Involved in Artemisinin Biosynthesis
대한약학회 학술대회
2000 .01
-
Molecular Surveillance of Pfkelch13 and Pfmdr1 Mutations in Plasmodium falciparum Isolates from Southern Thailand
Parasites, Hosts and Diseases
2019 .08
-
Computer-aided molecular docking of ligands into target proteins using FlexiDock
대한약학회 학술대회
2000 .01
-
Expression of Translationally Controlled Tumor Protein (TCTP) Gene of Dirofilaria immitis Guided by Transcriptomic Screening
Parasites, Hosts and Diseases
2014 .02
-
Heme Oxygenase-1 in Tumors: Therapeutic Implications
대한약학회 학술대회
2005 .01
-
Role of Translationally Controlled Tumor Protein in the Pathogenesis of Hypertension
대한약학회 학술대회
2005 .01
-
Using reverse docking to identify potential targets for ginsenosides
Journal of Ginseng Research
2017 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0