지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
A simple HPLC-UV method was developed and validated for the quantification of human serum isepamicin using phenylisocyanate as a derivatization agent. The linear calibration curve was obtained in the concentration range of $1{\sim}100{\mu}g/ml$ and LLOQ of $1{\mu}g/ml$. This method was validated with selectivity, linearity, precision and accuracy, leading to successful application for estimating the pharmacokinetic parameters of isepamicin in Korean healthy subjects following IV infusion of 800 mg isepamicin. The mean $t_{1/2}$ of isepamicin was $1.55{\pm}0.08hr$.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Nagabhushan, T. L / 1978 / The syntheses biological properties of 1-N-(S-4-amino-2-bydroxybutyryl)-gentamicin B and 1-N-(S-3-amino-2-hydroxypropionyl)-gentamicin B / J. Antibiot (Tokyo) 31:681
Tod, M / 2000 / Clinical pharmacokinetics and pharmacodynamics of isepamicin / Clin. Pharmacokinet 38:205
Barr, W. H / 1995 / Pharmacokinetics of isepamicin / J. Chemother 7:53
Miller, G. H / 1995 / The changing nature of aminoglycoside resistance mechanisms and the role of isepamicin-a new broad-spectrum aminoglycoside / J. Chemother 7:31
Jones, R. N / 1995 / Isepamicin (SCH 21420, 1-N-HAPA Gentamicin B): microbiological characteristics including antimicrobial potency and spectrum of activity / J. Chemother 7:7
Tod, M / 2000 / Clinical pharmacokinetics and pharmacodynamics of isepamicin / Clin. Pharmacokinet 38:205
Barr, W. H / 1995 / Pharmacokinetics of isepamicin / J. Chemother 7:53
Miller, G. H / 1995 / The changing nature of aminoglycoside resistance mechanisms and the role of isepamicin-a new broad-spectrum aminoglycoside / J. Chemother 7:31
Jones, R. N / 1995 / Isepamicin (SCH 21420, 1-N-HAPA Gentamicin B): microbiological characteristics including antimicrobial potency and spectrum of activity / J. Chemother 7:7
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Development of HPLC-UV method for the determination of silybinin in rat plasma: application to a pharmacokinetic study on commercial silymarin products
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Pharmacokinetics after Gastrectomy
대한외과학회 학술대회 초록집
2019 .10
-
Assessment tool based non-invasive molecular imaging for pharmacokinetic evaluation of oligonucleotides
한국실험동물학회 학술발표대회 논문집
2022 .07
-
External Validation of a Pharmacokinetic Model of Propofol for Target-Controlled Infusion in Children under Two Years Old
Journal of Korean Medical Science
2020 .01
-
Pharmacokinetics of polynemoraline C in mice
한국실험동물학회 학술발표대회 논문집
2022 .07
-
약동학 수식유도
Anesthesia and Pain Medicine
2018 .01
-
Impact of NR1I2, adenosine triphosphateebinding cassette transporters genetic polymorphisms on the pharmacokinetics of ginsenoside compound K in healthy Chinese volunteers
Journal of Ginseng Research
2019 .06
-
Simple determination and quantification of tofacitinib, a JAK inhibitor, in rat plasma, urine and tissue homogenates by HPLC and its application to a pharmacokinetic study
Journal of Pharmaceutical Investigation
2020 .01
-
신생아중환자의 약동학적 다양성에 영향을 미치는 요인
한국임상약학회지
2017 .01
-
Effect of lactic acid bacteria on the pharmacokinetics and metabolism of ginsenosides in mice
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Obesity and anesthetic pharmacology: simulation of target-controlled infusion models of propofol and remifentanil
Korean Journal of Anesthesiology
2021 .12
-
An experience on the model-based evaluation of pharmacokinetic drug-drug interaction for a long half-life drug
The Korean Journal of Physiology & Pharmacology
2021 .10
-
Pharmacokinetics of enrofloxacin HCl-2H₂O (Enro-C) in dogs and pharmacokinetic/pharmacodynamic Monte Carlo simulations against Leptospira spp.
Journal of Veterinary Science
2018 .09
-
항생제 Fluoroquinolones의 약동학 및 약력학에 관한 최신 정보
Urogenital Tract Infection
2015 .01
-
PAHs 농도 분포에 따른 GC/MS와 HPLC의 분석특성에 관한 연구
한국산업보건학회지
2015 .01
-
Analysis and optimization of drug solubility to improve pharmacokinetics
Journal of Pharmaceutical Investigation
2017 .03
-
약물계량학을 이용한 초기임상1상 시험 용량 예측 방법에 대한 비교연구
한국임상약학회지
2016 .01
-
Collaborative Pharmacokinetic–Pharmacodynamic Research for Optimization of Antimicrobial Therapy
Infection and Chemotherapy
2016 .01
-
맹종죽 열수추출물의 기능성 원료 표준화를 위한 HPLC 분석법 검증
생약학회지(Korean Journal of Pharmacognosy)
2024 .06
-
Pharmacokinetics of thalidomide in dogs: can feeding affect it? A preliminary study
Journal of Veterinary Science
2020 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0