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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
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- 1 - 10 (10page)
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Background: Previously, a linked pharmacokinetic-pharmacodynamic model (the Kim model) of propofol with concurrent infusion of remifentanil was developed for children aged 2–12 years. There are few options for pharmacokinetic-pharmacodynamic model of propofol for children under two years old. We performed an external validation of the Kim model for children under two years old to evaluate whether the model is applicable to this age group. Methods: Twenty-four children were enrolled. After routine anesthetic induction, a continuous infusion of 2% propofol and remifentanil was commenced using the Kim model. The target effect-site concentration of propofol was set as 2, 3, 4, and 5 μg/mL, followed by arterial blood sampling after 10 min of each equilibrium. Population estimates of four parameters—pooled bias, inaccuracy, divergence, and wobble—were used to evaluate the performance of the Kim model. Results: A total of 95 plasma concentrations were used for evaluation of the Kim model. The population estimate (95% confidence interval) of bias was −0.96% (−8.45%, 6.54%) and that of inaccuracy was 21.0% (15.0%–27.0%) for the plasma concentration of propofol. Conclusion: The pooled bias and inaccuracy of the pharmacokinetic predictions are clinically acceptable. Therefore, our external validation of the Kim model indicated that the model can be applicable to target-controlled infusion of propofol in children younger than 2 years, with the recommended use of actual bispectral index monitoring in clinical settings that remifentanil is present.
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참고문헌 (25)
참고문헌 신청
Marsh B / 1991 / Pharmacokinetic model driven infusion of propofol in children / Br J Anaesth 67(1):41~48
Schnider TW / 1998 / The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers / Anesthesiology 88(5):1170~1182
Schnider TW / 1999 / The influence of age on propofol pharmacodynamics / Anesthesiology 90(6):1502~1516
Murat I / 1996 / Pharmacokinetics of propofol after a single dose in children aged 1–3 years with minor burns. Comparison of three data analysis approaches / Anesthesiology 84(3):526~532
Rigouzzo A / 2008 / The relationship between bispectral index and propofol during target-controlled infusion anesthesia : a comparative study between children and young adults / Anesth Analg 106(4):1109~1116
Schnider TW / 1998 / The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers / Anesthesiology 88(5):1170~1182
Schnider TW / 1999 / The influence of age on propofol pharmacodynamics / Anesthesiology 90(6):1502~1516
Murat I / 1996 / Pharmacokinetics of propofol after a single dose in children aged 1–3 years with minor burns. Comparison of three data analysis approaches / Anesthesiology 84(3):526~532
Rigouzzo A / 2008 / The relationship between bispectral index and propofol during target-controlled infusion anesthesia : a comparative study between children and young adults / Anesth Analg 106(4):1109~1116
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