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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제3호
- 발행연도
- 2017.1
- 수록면
- 610 - 615 (6page)
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When Shigella infect host cells, various effecter molecules are delivered into the cytoplasm of the host cell through the type III secretion system (TTSS) to facilitate their invasion process and control the host immune responses. Among these effectors, the S. flexneri effector OspF dephosphorylates mitogen-activated protein kinases and translocates itself to the nucleus, thus preventing histone H3 modification to regulate expression of proinflammatory cytokines. Despite the critical role of OspF, the mechanism by which it localizes in the nucleus has remained to be elucidated. In the present study, we identified a potential small ubiquitinrelated modifier (SUMO) modification site within OspF and we demonstrated that Shigella TTSS effector OspF is conjugated with SUMO in the host cell and this modification mediates the nuclear translocation of OspF. Our results show a bacterial virulence factor can exploit host post-translational machinery to execute its intracellular trafficking.
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참고문헌 (23)
참고문헌 신청
Arbibe L / 2007 / An injected bacterial effector targets chromatin access for transcription factor NF-κB to alter transcription of host genes involved in immune responses /
Ashida H / 2011 / Shigella a re v ersatile m uco sal patho gens that circumvent the host innate immune system / Curr. Opin. Immunol 23 : 448 ~ 455
Bhavsar AP / 2007 / Manipulation of host-cell pathways by bacterial pathogens / Nature 449 : 827 ~ 834
Brennan DF / 2009 / Eliminylation: a posttranslational modification catalyzed by phosphothreonine lyases / Trends Biochem. Sci 34 : 108 ~ 114
Cossart P / 2004 / Bacterial invasion: the paradigms of enteroinvasive pathogens / Science 304 : 242 ~ 248
Ashida H / 2011 / Shigella a re v ersatile m uco sal patho gens that circumvent the host innate immune system / Curr. Opin. Immunol 23 : 448 ~ 455
Bhavsar AP / 2007 / Manipulation of host-cell pathways by bacterial pathogens / Nature 449 : 827 ~ 834
Brennan DF / 2009 / Eliminylation: a posttranslational modification catalyzed by phosphothreonine lyases / Trends Biochem. Sci 34 : 108 ~ 114
Cossart P / 2004 / Bacterial invasion: the paradigms of enteroinvasive pathogens / Science 304 : 242 ~ 248
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