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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 651 - 658 (8page)
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Small molecule peptides based on the amino sequence of thymosin ${\beta}4$ were prepared using solid-phase synthesis, and their bioactivities were investigated. Small molecule peptides are less than ten amino acids in size so can be produced on a large scale and, after modification, can easily penetrate blood vessels or tissues. We studied the ability of the small molecule peptides to promote wound healing, angiogenesis, and hair growth by examining their effects on the proliferation of human dermal fibroblasts, human umbilical vein endothelial cells, and human dermal papilla cells versus those of thymosin ${\beta}4$, vascular endothelial growth factor, and minoxidil, respectively. Several small molecule peptides promoted significantly more cell proliferation than the corresponding positive controls.
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