In Vivo Kinetics and Biodistribution of a HIV-1 DNA Vaccine after Administration in Mice

Kim, Byong-Moon; Lee, Dong-Sop; Choi, Jae-Hoon; Kim, Chae-Young; Son, Mi-Won; Suh, You-Suk; Baek, Kwan-Hyuck; Park, Ki-Seok; Sung, Young-Chul; Kim, Won-Bae

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자료유형: 학술저널

저자정보: Kim, Byong-Moon (Research Laboratories, Dong-A Pharm. Co., Ltd.) Lee, Dong-Sop (Research Laboratories, Dong-A Pharm. Co., Ltd.) Choi, Jae-Hoon (Research Laboratories, Dong-A Pharm. Co., Ltd.) Kim, Chae-Young (Research Laboratories, Dong-A Pharm. Co., Ltd.) Son, Mi-Won (Research Laboratories, Dong-A Pharm. Co., Ltd.) Suh, You-Suk (National Research Laboratory of DNA Medicine, Division of Molecular and Life Sciences, Pohang University of Science and Technology) Baek, Kwan-Hyuck (National Research Laboratory of DNA Medicine, Division of Molecular and Life Sciences, Pohang University of Science and Technology) Park, Ki-Seok (National Research Laboratory of DNA Medicine, Division of Molecular and Life Sciences, Pohang University of Science and Technology) Sung, Young-Chul (National Research Laboratory of DNA Medicine, Division of Molecular and Life Sciences, Pohang University of Science and Technology) Kim, Won-Bae (Research Laboratories, Dong-A Pharm. Co., Ltd.)

저널정보: 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제26권 제6호

발행연도: 2003.1

수록면: 493 - 498 (6page)

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In this study we have investigated the pharmacokinetics and tissue distribution of GX-12, a multiple plasmid DNA vaccine for the treatment of HIV-1 infection. Plasmid DNA was rapidly degraded in blood with a half-life of 1.34 min and was no longer detectable at 90 min after intravenous injection in mice. After intramuscular injection, plasmid DNA concentration in the injection site rapidly declined to less than 1 ％ of the initial concentration by 90 min post-injection. However, sub-picogram levels (per mg tissue) were occasionally detected for several days after injection. The relative proportions of the individual plasm ids of GX-12 remained relatively constant at the injection site until 90 min post-injection. The concentration of plasmid DNA in tissues other than the injection site peaked at 90 min post-injection and decreased to undetectable levels at 8 h post-injection. The rapid in vivo degradation of GX-12 and absence of persistence in non-target tissues suggest that the risk of potential gene-related toxicities by GX-12 administration, such as expression in non-target tissues, insertional mutagenesis and germline transmission, is minimal.

#GX-12 #Plasmid DNA vaccine #HIV-1 #Pharmacokinetics #Biodistribution

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