지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 172 - 177 (6page)
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초록· 키워드
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Objectives : The sub-acute toxic effects following repetitive intramuscular injection of two cervical cancer vaccines newly developed against human papillomaviruse (HPV)16/58/18 and HPV16 were investigated in female ICR (CrljOri: CD1) mice, and the no-observedadverse-effect-level (NOAEL) of the cervical cancer vaccines was estimated.
Methods : Female ICR mice (n=15 in each group) were exposed to a 1:1 mixture of two cervical cancer vaccines by repetitive intramuscular injection (once a week, 5 times) for 5 weeks. Mortality, body weight, organ weight, hematological/biochemical parameters, and histopathological effects were examined at different concentrations (0, 1×10<SUP>8</SUP>, 5×10<SUP>8</SUP>, and 2.5×10<SUP>9</SUP> copies/animal) of the cervical cancer vaccines.
Results : The cervical cancer vaccines did not show toxic responses for body weight, absolute/relative organ weight, hematological/biochemical parameters, or histopathological parameters.
Conclusions Female ICR mice exposed to vaccines for cervical cancer did not show any toxic response. We suggest that a NOAEL of the vaccine following repetitive intramuscular injection for 5 weeks is >2.5×10<SUP>9</SUP> copies/animal.
Methods : Female ICR mice (n=15 in each group) were exposed to a 1:1 mixture of two cervical cancer vaccines by repetitive intramuscular injection (once a week, 5 times) for 5 weeks. Mortality, body weight, organ weight, hematological/biochemical parameters, and histopathological effects were examined at different concentrations (0, 1×10<SUP>8</SUP>, 5×10<SUP>8</SUP>, and 2.5×10<SUP>9</SUP> copies/animal) of the cervical cancer vaccines.
Results : The cervical cancer vaccines did not show toxic responses for body weight, absolute/relative organ weight, hematological/biochemical parameters, or histopathological parameters.
Conclusions Female ICR mice exposed to vaccines for cervical cancer did not show any toxic response. We suggest that a NOAEL of the vaccine following repetitive intramuscular injection for 5 weeks is >2.5×10<SUP>9</SUP> copies/animal.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (18)
참고문헌 신청
Clifford GM / 2003 / Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis / Br J Cancer 88(1):63~73
이근화 / 2011 / 제주도에서 이루어진 자궁경부세포검사 결과와 HPV 감염양상 비교 연구 / Obstetrics & Gynecology Science 54(11):689~695
Division of STD Prevention / Prevention of genital HPV infection and sequelae: report of an external consultants’ meeting
Baudu A / 2014 / Prevalence and risk factors of human papillomavirus infection types 16/18/45 in a cohort of French females aged 15-23 years / J Epidemiol Glob Health 4(1):35~43
Chen Q / 2012 / Epidemiologic characterization of human papillomavirus infection in rural Chaozhou, eastern Guangdong Province of China / PLoS One 7(2):e32149
이근화 / 2011 / 제주도에서 이루어진 자궁경부세포검사 결과와 HPV 감염양상 비교 연구 / Obstetrics & Gynecology Science 54(11):689~695
Division of STD Prevention / Prevention of genital HPV infection and sequelae: report of an external consultants’ meeting
Baudu A / 2014 / Prevalence and risk factors of human papillomavirus infection types 16/18/45 in a cohort of French females aged 15-23 years / J Epidemiol Glob Health 4(1):35~43
Chen Q / 2012 / Epidemiologic characterization of human papillomavirus infection in rural Chaozhou, eastern Guangdong Province of China / PLoS One 7(2):e32149
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UCI(KEPA) : I410-ECN-0101-2016-539-002083284