지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 1,008 - 1,015 (8page)
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초록· 키워드
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Purpose: Bacillus Calmette-Guérin (BCG) vaccine has widely been used to immunize against tuberculosis, but its protective efficacy is variable in adult pulmonary tuberculosis, while it is not efficiently protective against progressive infection of virulent Mycobacterium tuberculosis strains. In this study, the protective effects of plasmid DNA vaccine constructs encoding IL_12 or IL_18 with the BCG vaccine were evaluated against progressive infection of M. tuberculosis, using mouse aerosol challenge model. Materials and Methods: Plasmid DNA vaccine constructs encoding IL_12 or IL_18 were constructed and mice were immunized with the BCG vaccine or with IL_12 DNA or IL_18 DNA vaccine constructs together with the BCG vaccine. Results: The BCG vaccine induced high level of interferon gamma (IFN-γ) but co-immunization of IL_12 or IL_18 DNA vaccine constructs with the BCG vaccine induced significantly higher level of IFN-γ than a single BCG vaccine. The BCG vaccine was highly protective at early stage of M. tuberculosis infection, but its protective efficacy was reduced at later stage of infection. The co-immunization of IL_12 DNA vaccine constructs with the BCG vaccine was slightly more protective at early stage of infection and was significantly more protective at later stage infection than a single BCG vaccine. Conclusion: Co-immunization of IL_12 DNA vaccine with the BCG vaccine induced more protective immunity and was more effective for protection against progressive infection of M. tuberculosis.
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참고문헌 (22)
참고문헌 신청
Derrick SC / 2004 / A polyvalent DNA vaccine expressing an ESAT6-Ag85B fusion protein protects mice against a primary infection with Mycobacterium tuberculosis and boosts BCG
Eunshil Jeong / 2011 / Intrinsic and Extrinsic Regulation of Innate Immune Receptors / Yonsei Medical Journal 52 (3) : 379 ~ 392
Fine PE / 1995 / Variation in protection by BCG: implications of and for heterologous immunity / Lancet 346 : 1339 ~ 1345
Flynn JL / 1993 / An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection / J Exp Med 178 : 2249 ~ 2254
Grode L / 2005 / Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin / J Clin Invest
Eunshil Jeong / 2011 / Intrinsic and Extrinsic Regulation of Innate Immune Receptors / Yonsei Medical Journal 52 (3) : 379 ~ 392
Fine PE / 1995 / Variation in protection by BCG: implications of and for heterologous immunity / Lancet 346 : 1339 ~ 1345
Flynn JL / 1993 / An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection / J Exp Med 178 : 2249 ~ 2254
Grode L / 2005 / Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin / J Clin Invest
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