지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 631 - 637 (7page)
이용수
초록· 키워드
오류제보하기
Genetic characteristics of Plasmodium falciparum may play a role in the treatment outcome of malaria infection. We have studied the association between diversity at the merozoite surface protein-1 (msp-1), msp-2, and glutamate-rich protein (glurp) loci and the treatment outcome of uncomplicated falciparum malaria patients along the Thai-Myanmar border who were treated with artemisinin derivatives combination therapy. P. falciparum isolates were collected prior to treatment from 3 groups of patients; 50 cases of treatment failures, 50 recrudescences, and 56 successful treatments. Genotyping of the 3 polymorphic markers was analyzed by nested PCR. The distribution of msp-1 alleles was significantly different among the 3 groups of patients but not the msp-2 and glurp alleles. The allelic frequencies of K1 and MAD20 alleles of msp1 gene were higher while RO33 allele was significantly lower in the successful treatment group. Treatment failure samples had a higher median number of alleles as compared to the successful treatment group. Specific genotypes of msp-1, msp-2, and glurp were significantly associated with the treatment outcomes. Three allelic size variants were significantly higher among the isolates from the treatment failure groups, i.e., K1<SUB>270-290</SUB>, 3D7<SUB>610-630</SUB>, G<SUB>650-690</SUB>, while 2 variants, K1<SUB>150-170</SUB>, and 3D7<SUB>670-690</SUB> were significantly lower. In conclusion, the present study reports the differences in multiplicity of infection and distribution of specific alleles of msp-1, msp-2, and glurp genes in P. falciparum isolates obtained from treatment failure and successful treatment patients following artemisinin derivatives combination therapy.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
Na-Bangchang K / 2007 / Current malaria status and distribution of drug resistance in East and Southeast Asia with special focus to Thailand / Tohoku J Exp Med 211:99~113
Na-Bangchang K / 2013 / Identification of resistance of Plasmodium falciparum to artesunate-mefloquine combination in an area along the Thai-Myanmar border : integration of chinico-parasitological response, systemic drug exposure, and in vitro parasite sensitivity / Malar J 12:263
Satimai W / 2013 / Efficacy and safety of artemether-lumefantrine(Coartem®)for the treatment of uncomplicated Plasmodium falciparum malaria in Ranong and Tak provinces / Dis Control J 39:129~138
Holder AA / 1992 / A malaria merozoite surface protein(MSP1)-structure, processing and function / Mem Inst Oswaldo Cruz 87:37~42
Prescott N / 1994 / Plasmodium falciparum genetic diversity can be characterized using the polymorphic merozoite surface antigen 2(MSA-2)gene as a single locus marker / Mol Biochem Parasitol 63:203~212
Na-Bangchang K / 2013 / Identification of resistance of Plasmodium falciparum to artesunate-mefloquine combination in an area along the Thai-Myanmar border : integration of chinico-parasitological response, systemic drug exposure, and in vitro parasite sensitivity / Malar J 12:263
Satimai W / 2013 / Efficacy and safety of artemether-lumefantrine(Coartem®)for the treatment of uncomplicated Plasmodium falciparum malaria in Ranong and Tak provinces / Dis Control J 39:129~138
Holder AA / 1992 / A malaria merozoite surface protein(MSP1)-structure, processing and function / Mem Inst Oswaldo Cruz 87:37~42
Prescott N / 1994 / Plasmodium falciparum genetic diversity can be characterized using the polymorphic merozoite surface antigen 2(MSA-2)gene as a single locus marker / Mol Biochem Parasitol 63:203~212
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UCI(KEPA) : I410-ECN-0101-2016-513-001292005