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자료유형
학술저널
저자정보
Zheng, Long-Tai (Department of Pharmacology, Kohwang Medical Research Institute, College of Medicine, Kyung Hee University) Baik, Haing-Woon (Department of Biochemistry and Molecular Biology, School of Medicine, Eulji University) Lee, Seong-Kyu (Department of Biochemistry and Molecular Biology, School of Medicine, Eulji University) Cho, Jeong-Je (Department of Microbiology, College of Medicine, Kyung Hee University) Park, Cheung-Seog (Department of Microbiology, College of Medicine, Kyung Hee University) Hong, Mee-Suk (Department of Pharmacology, Kohwang Medical Research Institute, College of Medicine, Kyung Hee University) Chung, Joo-Ho (Department of Pharmacology, Kohwang Medical Research Institute, College of Medicine, Kyung Hee University) Yim, Sung-Vin (Department of Pharmacology, Kohwang Medical Research Institute, College of Medicine, Kyung Hee University)
저널정보
대한독성유전단백체학회 Molecular & cellular toxicology Molecular & cellular toxicology 제2권 제4호
발행연도
2006.1
수록면
257 - 261 (5page)

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Signal transducer and activator of transcription 4 (STAT4) is one of the important mediators in generating inflammation and immune responses. To address the role of Stat4 in carrageenan induced acute inflammation, we performed paw edema measurement and 7.4 k mouse cDNA microarray analysis in carrageenan induced acute inflammation in Stat4 knockout (-/-) mice. Male BALB/c (n=8) and Stat4 -/- (n=5) were used and paw edema was induced with injection of $30\;{\mu}L$ of 1% carrageenan into plantar surface of right hind paw. Next, we isolated the mRNA in mouse whole brain and analyzed cDNA microarray profiles for the changes of the brain expression in Stat4 -/- mice. Interestingly, the increase in paw volume of Stat4 -/- mice was reduced by about 30% as compared to that of wild type. The cDNA microarray analysis revealed the altered expressions of several cytokines (Tnf, Il6, and Il4) and pain-associated proteins (Ptgs2, Gabra6, and Gabbr1) in Stat4 -/- mice. Our results suggest that Stat4 may be related to the inhibitory responses on carrageenan induced acute inflammation.

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