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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제43권 제5호
- 발행연도
- 2009.1
- 수록면
- 393 - 399 (7page)
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Background : Signal transducers and activators of transcription 3 (STAT3) and protein kinase substrate p36 may be involved in cell proliferation, differentiation and growth. Methods : Immunohistochemistry for STAT3 and p36 was performed in 46 patients with hepatocellular carcinoma (HCC). Results : STAT3 staining was present in the cytoplasm and/or nucleus, while p36 staining was present in the nucleus. STAT3 and p36 expression occurred in 78.3% (36/46) and 47.8% (22/46) of HCC patients, respectively. However, no correlation was found between STAT3 and p36 protein expression (p>0.05). Enhanced expression of STAT3 was negatively correlated with portal vein invasion (p=0.033). Expression of STAT3 in the nucleus was correlated with tumor grade (p=0.004). Enhanced expression of p36 was correlated with tumor grade (p=0.031). HCC was correlated with HBV infection (p=0.032). The patients’ 5- year survival was related to expression of p36 (p=0.044), but not to total STAT3 or nuclear STAT3 (p>0.05). Conclusions : The enhanced expression of STAT3 in the nucleus and the enhanced expression of p36 are associated with the aggressive phenotype of HCC. Enhanced p36 expression may contribute to poor survival of patients with HCC.
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참고문헌 (24)
참고문헌 신청
Biswas KK / 2006 / Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt / FE
Bosch FX / 1999 / Epidemiology of primary liver cancer / Semin Liver Dis 19 : 271 ~ 285
Bromberg J / 2000 / The role of STATs in transcriptional control and their impact on cellular function / Oncogene 19 : 2468 ~ 2473
Burgoyne RD / 1988 / Calpactin in exocytosis / Nature 331 : 20 ~
Coffer PJ / 2000 / The role of STATs in myeloid differentiation and leukemia / Oncogene 19 : 2511 ~ 2522
Bosch FX / 1999 / Epidemiology of primary liver cancer / Semin Liver Dis 19 : 271 ~ 285
Bromberg J / 2000 / The role of STATs in transcriptional control and their impact on cellular function / Oncogene 19 : 2468 ~ 2473
Burgoyne RD / 1988 / Calpactin in exocytosis / Nature 331 : 20 ~
Coffer PJ / 2000 / The role of STATs in myeloid differentiation and leukemia / Oncogene 19 : 2511 ~ 2522
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