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논문 기본 정보

자료유형
학술저널
저자정보
Myung, Seung-Woon (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) Min, Hye-Ki (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) Jin, Chang-Bae (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) Kim, Myung-Soo (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) Lee, Seung-Mok (IL YANG Pharmaceutical Company, LTD., Central Research Laboratory) Chung, Gi-Ju (IL YANG Pharmaceutical Company, LTD., Central Research Laboratory) Park, Seong-Jun (IL YANG Pharmaceutical Company, LTD., Central Research Laboratory) Kim, Dong-Yeon (IL YANG Pharmaceutical Company, LTD., Central Research Laboratory) Cho, Hyun-Woo (Department of Chemistry, KyunGi University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제22권 제2호
발행연도
1999.1
수록면
189 - 193 (5page)

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Reversed-phase high-performance liquid chromatography/mass spectrometry (HPLC/MS) with an eletcrospray ionization (ESI) interface was applied to the identification of metabolites of IY81149 in the rat plasma. Fragments obtained using collision-induced dissociation (CID) in both positive and negative modes were utilized to elucidate the structure of metabolites. The eluent from the conventional HPLC column was split and directly introduced into an ESI-mass spectrometer for the identification of the structures. the CID technique allowed the sensitive identification of sulfonyl-IY81149 and hydroxy-IY81149 from the rat plasma.

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