지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 107 - 114 (8page)
이용수
초록· 키워드
오류제보하기
Mass spectrometry (MS) is a very powerful instrument that can be used to analyze a wide range of materials such as proteins, peptides, DNA, drugs, and polymers. The process typically involves either chemical or electron (impact) ionization of the analyte. The resulting charged species or fragment is subsequently identified by the detector. Usually, single mass uses source-induced dissociation (SID), whereas mass/mass uses collision-induced dissociation (CID) to analyze the chemical fragmentations Each technique has its own advantages and disadvantages. While CID is most effective for the analysis of pure substances, multiple-step MS is a powerful technique to get structural data. Analysis of veterinary drugs ampicillin, chloramphenicol, ciprofloxacin, and oxytetracycline serves to highlight the slight differences between SID and CID. For example, minor differences were observed between ciprofloxacin and oxytetracycline via SID or CID. However, distinct fragmentation patterns were observed for ampicllin depending on the analysis method. Both SID and CID showed similar fragmentation spectra but different signal intensities for chloramphenicol. There are several factors that can influence the fragmentation spectra, such as the collision energy, major precursor ion, electrospray mode (positive or negative), and sample homogeneity. Therefore, one must select a fragmentation method on an empirical and case-by-case basis.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
Gabelica, V. / 2005 / Internal energy and fragmentation of ions produced in electrospray sources / Mass Spectrom. Rev. 24:566~587
Abrankó, L. / 2011 / In-source fragmentation and accurate mass analysis of multiclass flavonoid conjugates by electrospray ionization time-offlight mass spectrometry / J. Mass Spectrom. 46:478~488
Tiller, P.R. / 1999 / Evaluating the Differences between Source CID or Real MS/MS :719
Marquet, P. / 2000 / In-source CID mass spectral libraries for the “general unknown” screening of drugs and toxicants / Analusis 28:925~934
Abdelhameed, A. S. / 2013 / Induced in-source fragmentation pattern of certain novel (1Z,2E)-N-(aryl)propanehydrazonoyl chlorides by electrospray mass spectrometry (ESl-MS/MS) / Chem. Cent. J. 7:16
Abrankó, L. / 2011 / In-source fragmentation and accurate mass analysis of multiclass flavonoid conjugates by electrospray ionization time-offlight mass spectrometry / J. Mass Spectrom. 46:478~488
Tiller, P.R. / 1999 / Evaluating the Differences between Source CID or Real MS/MS :719
Marquet, P. / 2000 / In-source CID mass spectral libraries for the “general unknown” screening of drugs and toxicants / Analusis 28:925~934
Abdelhameed, A. S. / 2013 / Induced in-source fragmentation pattern of certain novel (1Z,2E)-N-(aryl)propanehydrazonoyl chlorides by electrospray mass spectrometry (ESl-MS/MS) / Chem. Cent. J. 7:16
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UCI(KEPA) : I410-ECN-0101-2014-510-003293221