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General Pharmacology of IY-80843, a new $H_2-Receptor$ Antagonist;Effects on the Central Nervous and Cardiovascular Systems
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논문 기본 정보

Type
Academic journal
Author
Kim, Eun-Joo (Korea Research Institute of Chemical Technology) Shin, Hwa-Sup (Korea Research Institute of Chemical Technology) Ryu, Shi-Yong (Korea Research Institute of Chemical Technology) Lee, Byung-Ho (Korea Research Institute of Chemical Technology) Cho, Soon-Hyun (Il Yang Pharmaceutical Co. Ltd)
Journal
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제18권 제1호 SCOPUS
Published
1995.1
Pages
1 - 7 (7page)

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General Pharmacology of IY-80843, a new $H_2-Receptor$ Antagonist;Effects on the Central Nervous and Cardiovascular Systems
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IY-80843, N[2-(2-methoxyphenyl)ethyl]-N'-[4-(lmidazole-4-yl)phenyl] formamidine, is a new potent $H_2-receptor$ anagonist. The potential secondary pharmacologic effects of this agent, on the central nervous and cardiovascular systems were studied. IY-80843 caused ptosis, suppression of locomotion, hypotehrmia, prolongation of sleeping time and hypotensive effects in mice, rats and dogs. These results suggest that IY-80843 affects the funcition of the central nervous and cardiovascular systems in a dose-dependent manner.
#IY-80843 #$H_2-antagonis$ #Pharmacology #Central nervous sytstem #Cardiovascular system

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