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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 저널정보
- 한국응용약물학회 한국응용약물학회 추계학술발표논문집 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
- 발행연도
- 2003.1
- 수록면
- 88 - 88 (1page)
이용수
이 논문의 연구 히스토리 (2)
2003
Cytochrome P-450 3A4 proximal promoter activity by histone deacetylase inhibitor in HepG2 cell.
Kim
,
Ja-Young
,
Ahn
외 3명
대한약학회 학술대회
2003.01
학술대회자료
Cytochrome P-450 3A4 proximal promoter activity by histone deacetylase inhibitor in HepG2 cell.
Kim
,
Ja-Young
,
Ahn
외 3명
한국응용약물학회 추계학술발표논문집
2003.01
학술대회자료
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초록· 키워드
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Cytochrome P-450 3A4 (CYP3A4) is major enzyme in human liver, the role of this is detoxification and metabolizing more than 50% clinical drugs in use. Expression of CYP3A4 is transciptionally regulated by the Pregnenolone X receptor (PXR), of which human form is Steroid and Xenobiotics receptor (SXR). SXR is activated by wide range of endogenous and exogenous compounds, and then induces CYP3A4 gene expression. In the previous study, it has been known that proximal promoter (-864 to +64) does not response to chemical inducers such as pregnenolone 16a-carbonitrile (PCN), Rifampicin, Estrogen in terms of transcription of CYP 3A4 in cultured cells. Here, we developed luciferase reporter gene assay system to detect SXR-based CYP 3A4 transcriptional activity. We have used CYP3A4-Luc plasmid that contains proximal promoter of human CYP3A4 gene upstream of the luciferase gene. We did transient transfection of 3A4-luciferase gene and SXR. In the HepG2 cells transfected with CYP3A4-Luc, when rifampicin treatment was combined with histone deacetylase inhibitor (HDAC Inhibitor), such as Trichostatin A, Hc-toxin and IN 2001 of the luciferase activity was induced 10-20 fold over control.
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Cytochrome P-450 3A4 proximal promoter activity by histone deacetylase inhibitor in HepG2 cell.
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Trichostatin A, a Histone Deacetylase Inhibitor Stimulate CYP3A4 Proximal Promoter Activity in Hepa-I Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
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Histone Deacetylase Inhibitor Stimulate CYP3A4 Proximal Promoter Activity in HepG2 Cells
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No Role of Protected Region B of Human Cytochrome P4501A2 Gene (CYP1A2) As an AP-1 Response Element
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Human CYP1A2 Promoter Fused-Luciferase Gene Constructs Hardly Respond to Polycyclic Hydrocarbons in Transient Transfection Study in HepG2 Cells
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생물정신의학
2000 .01
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Bioassays of Polycyclic Aromatic Hydrocarbons using CYP1A1-luciferase Reporter Gene Expression System in Human Breast Cancer MCF-7 Cells
한국환경성돌연변이·발암원학회지
2003 .06
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약물대사효소 CYP2C19, CYP2D6의 다형성과 사상체질의 관련성 연구
대한한의학회지
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