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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 91 - 96 (6page)
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초록· 키워드
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Graves’ ophthalmopathy (GO) is an autoimmune disease associated with orbital inflammation and fibrosis which can result in lid retraction, soft tissue swelling, and proptosis. Treatment should rely on a thorough assessment of the activity and severity of GO. Control of risk factors for GO progression and topical treatments for dry eye are recommended for all patients. In mild GO, a careful observation is usually sufficient. In moderate-to-severe and active GO, high-dose intravenous glucocorticoids can be considered an initial treatment. The most common schedule for intravenous glucocorticoids is a cumulative dose of 4.5 g of methylprednisolone, divided into 12 weekly infusions (6 weekly infusions of 0.5 g, followed by 6 weekly infusions of 0.25 g). Orbital radiation has been shown to be an effective secondary treatment in patients with active GO unresponsive to intravenous glucocorticoids. Rehabilitative surgery is needed in patients with GO when the disease is associated with a significant impact on quality of life or visual function after the disease has been inactive for at least 6 months.
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참고문헌 (47)
참고문헌 신청
Bartley GB / 1994 / The epidemiologic characteristics and clinical course of ophthalmopathy associated with autoimmune thyroid disease in Olmsted County, Minnesota / Trans Am Ophthalmol Soc 92:477~588
Smith TJ / 1991 / Stimulation of glycosaminoglycan accumulation by interferon gamma in cultured human retroocular fibroblasts / J Clin Endocrinol Metab 72(5):1169~1171
Smith TJ / 2004 / Immunoglobulins from patients with Graves'disease induce hyaluronan synthesis in their orbital fibroblasts through the self-antigen, insulin-like growth factor-I receptor / J Clin Endocrinol Metab 89(10):5076~5080
Wiersinga WM / 2002 / Epidemiology and prevention of Graves' ophthalmopathy / Thyroid 12(10):855~860
Mourits MP / 1997 / Clinical activity score as a guide in the management of patients with Graves' ophthalmopathy / Clin Endocrinol (Oxf) 47(1):9~14
Smith TJ / 1991 / Stimulation of glycosaminoglycan accumulation by interferon gamma in cultured human retroocular fibroblasts / J Clin Endocrinol Metab 72(5):1169~1171
Smith TJ / 2004 / Immunoglobulins from patients with Graves'disease induce hyaluronan synthesis in their orbital fibroblasts through the self-antigen, insulin-like growth factor-I receptor / J Clin Endocrinol Metab 89(10):5076~5080
Wiersinga WM / 2002 / Epidemiology and prevention of Graves' ophthalmopathy / Thyroid 12(10):855~860
Mourits MP / 1997 / Clinical activity score as a guide in the management of patients with Graves' ophthalmopathy / Clin Endocrinol (Oxf) 47(1):9~14
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