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Update on Glucocorticoid Induced Osteoporosis
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논문 기본 정보

Type
Academic journal
Author
CHO Soo-Kyung (한양대학교) SUNG Yoon-Kyoung (한양대학교)
Journal
Korean Endocrine Society Endocrinology and Metabolism Endocrinology and Metabolism Vol.36 No.3 KCI Accredited Journals
Published
2021.1
Pages
536 - 543 (8page)

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Update on Glucocorticoid Induced Osteoporosis
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Abstract· Keywords

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Glucocorticoids are used to treat many autoimmune and inflammatory diseases. However, an adverse systemic effect is a deleterious effect on bone, which may lead to glucocorticoid-induced osteoporosis, characterized by a rapid and transient increase in bone resorption and fracture risk, which may increase rapidly within 3 months of commencing oral glucocorticoids. Therefore, early risk assessment and intervention are crucial for preventing fractures in patients receiving glucocorticoids. Recent practice guidelines recommend an assessment for fracture risk in patients beginning or receiving glucocorticoids for more than 3 months, and they have suggested fracture risk assessment tool values for identifying patients who need preventive treatment. Bisphosphonates are currently the recommended first-line therapy for the prevention and treatment of glucocorticoid-induced osteoporosis. These have been shown to increase the bone mineral density in the spine and hip and to decrease the incidence of vertebral fractures. Recently, a more potent antiresorptive agent, denosumab, has been shown to increase the bone density in patients receiving glucocorticoids. Teriparatide has been shown to have a preventive effect on vertebral fractures, but not on nonvertebral fractures. In this article we aimed to providean update on glucocorticoid-induced osteoporosis by focusing on the assessment of its risk and treatment options.
#Glucocorticoids #Osteoporosis #Therapeutics

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References (60)

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Hench P / 1950 / Effects of cortisone in the rheumatic diseases / Lancet 2:483~484 google schola Lane NE / 1998 / The science and therapy of glucocorticoid-induced bone loss / Endocrinol Metab Clin North Am 27:465~483 google schola Overman RA / 2013 / Prevalence of oral glucocorticoid usage in the United States: a general population perspective / Arthritis Care Res(Hoboken) 65:294~298 google schola Fardet L / 2011 / Prevalence of long-term oral glucocorticoid prescriptions in the UK over the past 20years / Rheumatology(Oxford) 50:1982~1990 google schola Gudbjornsson B / 2002 / Prevalence of long term steroid treatment and the frequency of decision making to prevent steroid induced osteoporosis in daily clinical practice / Ann Rheum Dis 61:32~36 google schola

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