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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 39 - 45 (7page)
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This article examines the current knowledge of the effects of both exogenous and endogenous glucocorticoids on bone and muscle. It demonstrates the similarity of effects of supraphysiologic loads of glucocorticoids regardless of whether they enter the body in the form of medication or are manufactured by the body in response to stimuli such as inflammation. The effects of endogenous glucocorticoids and the systemic inflammatory response resulting from pediatric burn injury are compared and the difficulty in sorting out which of the two factors is responsible for the ultimate effects on bone and muscle is pointed out. The focus then switches to the body's response to the influence of both glucocorticoids and inflammatory cytokines and evidence supporting a common pathway of response to oxidative damage caused by both is discussed. Current recommended medical management of glucocorticoid-induced bone and muscle loss is discussed and the failure to reconcile current management with known mechanisms is highlighted.
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등록된 정보가 없습니다.
참고문헌 (45)
참고문헌 신청
National Institute of Diabetes / 2008 / National Endocrine and Metabolic Diseases Information Service, Cushing's disease / NIH Publication 08-300 :1~10
Cushing H. / 1932 / The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism) / Bull Johns Hopkins Hosp 50:137~195
Ziegler R / 1998 / Glucocorticoid-induced osteoporosis: prevention and treatment / Steroids 63:344~348
Huybers S / 2007 / Prednisolone-induced Ca2þ malabsorption is caused by diminished expression of the epithelial Ca2þchannelTRPV6 / Am J Physiol Gastrointest Liver Physiol 292:G92
Zikan V / 2012 / Bone mineral density and body composition in men with multiple sclerosis chronically treated with low dose steroids / Physiol 61:405~417
Cushing H. / 1932 / The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism) / Bull Johns Hopkins Hosp 50:137~195
Ziegler R / 1998 / Glucocorticoid-induced osteoporosis: prevention and treatment / Steroids 63:344~348
Huybers S / 2007 / Prednisolone-induced Ca2þ malabsorption is caused by diminished expression of the epithelial Ca2þchannelTRPV6 / Am J Physiol Gastrointest Liver Physiol 292:G92
Zikan V / 2012 / Bone mineral density and body composition in men with multiple sclerosis chronically treated with low dose steroids / Physiol 61:405~417
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