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Cellular Senescence in Arterial Diseases
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논문 기본 정보

Type
Academic journal
Author
Journal
한국지질동맥경화학회(구 한국지질학회) 지질·동맥경화학회지 지질·동맥경화학회지 제9권 제1호 KCI Accredited Journals
Published
2020.1
Pages
79 - 91 (13page)

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Cellular Senescence in Arterial Diseases
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Cell-proliferation potency is limited, as cells cannot proceed through the cell cycle continually. Instead, they eventually show an irreversible arrest of proliferation, commonly referred to as cellular senescence. Following the initial discovery of this phenomenon by Hayflick et al., studies have indicated that cells are also destined to undergo aging. In addition to the irreversible termination of proliferation, senescent cells are characterized by a flattened and enlarged morphology. Senescent cells become pro-inflammatory and contribute to the initiation and maintenance of sustained chronic sterile inflammation. Aging is associated with the accumulation of senescent cells in the cardiovascular system, and in general these cells are considered to be pathogenic because they mediate vascular remodeling. Recently, genetic and pharmacological approaches have enabled researchers to eliminate senescent cells both in vitro and in vivo. The term “senolysis” is now used to refer to the depletion of senescent cells, and evidence indicates that senolysis contributes to the reversal of age-related pathogenic phenotypes without the risk of tumorigenesis. The concept of senolysis has opened new avenues in research on aging, and senolysis may be a promising therapeutic approach for combating age-related disorders, including arterial diseases.

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References (98)

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Chien KR / 2005 / Longevity and lineages : toward the integrative biology of degenerative diseases in heart, muscle, and bone / Cell 120:533~544 google schola López-Otín C / 2013 / The hallmarks of aging / Cell 153:1194~1217 google schola Lakatta EG / 2015 / So! What's aging? Is cardiovascular aging a disease? / J Mol Cell Cardiol 83:1~13 google schola Triposkiadis F / 2019 / Cardiovascular aging and heart failure : JACC review topic of the week / J Am Coll Cardiol 74:804~813 google schola Yoshii M / 2006 / The relationship between coronary artery disease and parameters of arteriosclerosis in patients with ischemic heart disease / J Hypertens 24:214~215 google schola

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