지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2025.2
- 수록면
- 143 - 161 (19page)
이용수
초록· 키워드
오류제보하기
Aging significantly diminishes T cell immunity, increasing susceptibility to infections and reducing vaccine efficacy in older individuals. Metabolism plays a key role in T cell function, shaping their energy requirements, activation, and differentiation. Recent studies highlight altered metabolic signaling as a pivotal factor in T cell aging, influencing the ability of T cells to maintain quiescence, respond to activation, and differentiate into functional subsets. Aberrant metabolic pathways disrupt the quiescence of aged T cells and skew their differentiation toward short-lived, pro-inflammatory effector T cells while hindering the generation of long-lived memory and T follicular helper cells. These changes contribute to a hyper-inflammatory state, exacerbate chronic low-grade inflammation, and compromise immune homeostasis. In this review, we explore how metabolic signaling is altered during T cell aging and the resulting functional impacts. We also discuss therapeutic approaches aimed at restoring proper T cell differentiation, improving vaccine responses, and rejuvenating immune function in older populations.
목차
ABSTRACT
INTRODUCTION
T CELL RESPONSE AND METABOLIC SIGNALING
NAÏVE T CELL MAINTENANCE IN AGING
T CELL ACTIVATION AND EFFECTOR DIFFERENTIATION IN AGING
MEMORY AND TFH CELL DIFFERENTIATION IN AGING
THERAPEUTIC STRATEGIES AND CHALLENGES IN RESTORING AGED T CELL RESPONSES
CONCLUSIONS AND FUTURE DIRECTIONS
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
Parasites, Hosts and Diseases
2016 .10
-
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes
Immune Network
2017 .06
-
Heterogeneity of Islet Cells during Embryogenesis and Differentiation
Diabetes and Metabolism Journal
2023 .03
-
Regulation of Th2 Cell Immunity by Dendritic Cells
Immune Network
2016 .02
-
Metabolic Reprogramming by the Excessive AMPK Activation Exacerbates Antigen-Specific Memory CD8+ T Cell Differentiation after Acute Lymphocytic Choriomeningitis Virus Infection
Immune Network
2019 .04
-
T-Cell Senescence in Human Metabolic Diseases
Diabetes and Metabolism Journal
2024 .09
-
T Cell Immune Responses against SARS-CoV-2 in the With Corona Era
대한의생명과학회지
2022 .12
-
Molecular Mechanisms of T Helper Cell Differentiation and Functional Specialization
Immune Network
2023 .02
-
Th17 Cell and Inflammatory Infiltrate Interactions in Cutaneous Leishmaniasis: Unraveling Immunopathogenic Mechanisms
Immune Network
2024 .04
-
Regeneration of Damaged Tissues After Cell Transplantation in Cardiovascular Animal Models
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Early Growth Response-1 Plays a Non-redundant Role in the Differentiation of B Cells into Plasma Cells
Immune Network
2015 .06
-
IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
Immune Network
2020 .02
-
Self-organized insulin-producing β-cells differentiated from human omentum-derived stem cells and their in vivo therapeutic potential
생체재료학회지
2023 .03
-
Tumor Induces the Expansion of Foxp3+CD25high and CD11b+Gr-1+ Cell Population in the Early Phase of Tumor Progression
대한의생명과학회지
2015 .12
-
Unusual Suspects in the Development of Obesity- Induced Inflammation and Insulin Resistance: NK cells, iNKT cells, and ILCs
Diabetes and Metabolism Journal
2017 .01
-
Re-defining T-Cell Exhaustion: Subset, Function, and Regulation
Immune Network
2020 .02
-
Research on Epstein-Barr virus immunity using a mouse model: from new insights to cancer immunotherapeutic applications
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Two-dimensional material-based bionano platforms to control mesenchymal stem cell differentiation
생체재료학회지
2018 .06
-
The Function of Memory CD8+ T Cells in Immunotherapy for Human Diseases
Immune Network
2023 .02
이 논문과 함께 이용한 논문
Oxidized LDL Accelerates Cartilage Destruction and Inflammatory Chondrocyte Death in Osteoarthritis by Disrupting the TFEB-Regulated Autophagy-Lysosome Pathway
Jeong Su Lee
,
Yun Hwan Kim
,
JooYeon Jhun
외 9명
Immune Network
2024
.06
Cytokine Storm Related to CD4⁺ T Cells in Influenza Virus-Associated Acute Necrotizing Encephalopathy
Shushu Wang
,
Dongyao Wang
,
Xuesong Wang
외 6명
Immune Network
2024
.04
Low-Dose Radiotherapy Attenuates Experimental Autoimmune Arthritis by Inducing Apoptosis of Lymphocytes and Fibroblast-Like Synoviocytes
Bo-Gyu Kim
,
Hoon Sik Choi
,
Yong-ho Choe
외 7명
Immune Network
2024
.08
Germinal Center Response to mRNA Vaccination and Impact of Immunological Imprinting on Subsequent Vaccination
Wooseob Kim
Immune Network
2024
.08
미토콘드리아 기능 이상과 암
한유선
,
제갈명은
,
김영진
생명과학회지
2019
.09
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-151-25-02-092461025