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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.8
- 수록면
- 186 - 190 (5page)
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초록· 키워드
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Cytomegalovirus (CMV) infection in healthy individuals is usually asymptomatic and results in latent infection. CMV reactivation occasionally occurs in healthy individuals according to their immune status over time. T cell responses to CMV are restricted to a limited number of immunodominant epitopes, as compared to responses to other chronic or persistent viruses. This response results in progressive, prolonged expansion of CMV-specific CD8?T cells, termed ‘memory inflation’. The expanded CMVspecific CD8? T cell population is extraordinarily large and is more prominent in the elderly. CMV-specific CD8?T cells possess rather similar phenotypic and functional features to those of replicative senescent T cells. In this review, we discuss the general features of CMV-specific inflationary memory T cells and the factors involved in memory inflation.
목차
INTRODUCTION
CHARACTERISTICS OF INFLATIONARY MEMORY T CELLS
FACTORS INVOLVED IN MEMORY T CELL INFLATION
CMV, MEMORY INFLATION AND T CELL SENESCENCE
REFERENCES
참고문헌 (49)
참고문헌 신청
[학술지(정기간행물)] - Sierro, S. / 2005 / Evolution of diverse antiviral CD8+ T cell populations after murine cytomegalovirus infection / Eur. J. Immunol 35 : 1113 ~ 1123
[학술지(정기간행물)] - Munks, M. W. / 2006 / Four distinct patterns of memory CD8 T cell responses to chronic murine cytomegalovirus infection / J. Immunol 177 : 450 ~ 458
[학술지(정기간행물)] - Snyder, C. M. / 2008 / Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells / Immunity 29 : 650 ~ 659
[학술지(정기간행물)] - O'Hara, G. A. / 2012 / Memory T cell inflation: understanding cause effect / Trends Immunol 33 : 84 ~ 90
[학술지(정기간행물)] - Koch, S. / 2007 / Cytomegalovirus infection: a driving force in human T cell immunosenescence / Ann. N. Y. Acad. Sci 1114 : 23 ~ 35
[학술지(정기간행물)] - Munks, M. W. / 2006 / Four distinct patterns of memory CD8 T cell responses to chronic murine cytomegalovirus infection / J. Immunol 177 : 450 ~ 458
[학술지(정기간행물)] - Snyder, C. M. / 2008 / Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells / Immunity 29 : 650 ~ 659
[학술지(정기간행물)] - O'Hara, G. A. / 2012 / Memory T cell inflation: understanding cause effect / Trends Immunol 33 : 84 ~ 90
[학술지(정기간행물)] - Koch, S. / 2007 / Cytomegalovirus infection: a driving force in human T cell immunosenescence / Ann. N. Y. Acad. Sci 1114 : 23 ~ 35
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UCI(KEPA) : I410-ECN-0101-2016-511-001834843