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Review of Health Effects Caused by Chloromethylisothiazolinone (CMIT) and Methylisothiazolinone (MIT) - Focusing on Humidifier Disinfectant-associated Lung Injury (HDLI) -
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Chloromethylisothiazolinone (CMIT)과 Methylisothiazolinone (MIT)의 건강영향에 대한 고찰 - 가습기 살균제 폐 손상을 중심으로 -

논문 기본 정보

Type
Academic journal
Author
Journal
Korean Society of Envlromental Health 한국환경보건학회지 한국환경보건학회지 제46권 제3호 KCI Excellent Accredited Journal
Published
2020.1
Pages
312 - 323 (12page)

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Review of Health Effects Caused by Chloromethylisothiazolinone (CMIT) and Methylisothiazolinone (MIT) - Focusing on Humidifier Disinfectant-associated Lung Injury (HDLI) -
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Research history (10)

2021

A Scientific Critique of a Korean Court’s Acquittal for Involuntary Manslaughter Related to 5-chloro-2-methylisothiazol-3(2H)-one/ 2-methylisothiazol-3(2H)-one (CMIT/MIT), a Humidifier Disinfectant (HD) Part II: Animal experiments, criteria for HD lung injury, and causality on individual levels
Dong-Uk Pa ,  k ,  Kyung Ehi Zoh and others 6 한국환경보건학회지 2021.06 Academic journal
가습기 살균제 건강피해 규명에서 노출평가의 역할과 쟁점 -CMIT/MIT 형사재판 중심-
박동욱 대한직업환경의학회 학술대회 논문집 2021.05 Proceeding
A Scientific Critique of a Korean Court’s Acquittal for Involuntary Manslaughter Related to 5-chloro-2-methylisothiazol-3(2H)-one/ 2-methylisothiazol-3(2H)-one (CMIT/MIT), a Humidifier Disinfectant (HD) Part I: Material safety, exposure and delivery to target organ from an HD perspective
pa ,  kdonguk ,  Kyung Ehi Zoh and others 5 한국환경보건학회지 2021.04 Academic journal

2020

Comprehensive Review on Humidifier Disinfectant (HD) Products, Focusing on the Number of Products and Their Disinfectant Type
pa ,  kdonguk ,  Seunghee Lee and others 5 한국환경보건학회지 2020.10 Academic journal
Review of Health Effects Caused by Chloromethylisothiazolinone (CMIT) and Methylisothiazolinone (MIT) - Focusing on Humidifier Disinfectant-associated Lung Injury (HDLI) -
pa ,  kdonguk ,  김지원 and others 6 한국환경보건학회지 2020.01 Academic journal
The Role of Exposure Assessment of Humidifier Disinfectant (HD) in the Program to Monitor HD Associated Health Problems
Dong-Uk Pa ,  k ,  Soyoung Pa and others 12 한국환경보건학회지 2020.01 Academic journal
Abrupt Rise of Humidifier Disinfectants Associated Health Problems Since 2008: Is It Chance or Inevitable?
pa ,  kdonguk ,  Soyoung Pa and others 7 한국환경보건학회지 2020.01 Academic journal

2018

A Strategy for Exposure Assessment of Humidifier Disinfectant Associated to Health Effects
pa ,  kdonguk 한국환경보건학회지 2018.01 Academic journal

2017

Review on Safety and Health Information on Humidifier Disinfectant
pa ,  kdonguk ,  Seunghee Lee and others 4 한국환경보건학회지 2017.01 Academic journal

2016

Distribution of Health Problems Associated with Humidifier Disinfectant by Year
pa ,  kdonguk ,  Seung-Hun Ryu 한국환경보건학회지 2016.12 Academic journal
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Abstract· Keywords

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Objective: This study aimed to summarize the physiochemical properties, toxicity, and legal regulation ofchloromethylisothiazolinone (CMIT) and/or methylisothiazolinone (MIT), review the health effects caused by exposure to CMIT/MIT, and evaluate the individual association of lung injury with the use of humidifier disinfectants (HD) containing a mixture of CMIT and MIT. Method: A literature review was conducted by searching keywords such as CMIT, MIT, health effect, dermatitis, asthma, and lung injury, either singly or combined. Results: Both CMIT and/or MIT were found to be associated with the development of several types of adverse health effects. In particular, respiratory diseases including asthma, nasal symptoms, cough, and rhinitis were caused by the use of products including CMIT or/and MIT. The mixture of CMIT/MIT has been banned in cosmetics. As of the end of 2017, nine patients who were confirmed to have HD associated lung injury (HDLI) were found to have used only an HD brand containing CMIT and MIT. Their responses regarding the name of the HD used could be trustworthy based on the short duration of HD use (less than six months) before the onset of HDLI and frequent use of HD per day. Conclusion: According to the toxicity and HDLI cases, the use of HD containing CMIT and /or MIT can cause fatal lung injury. Further study with manufacturers’ assistance is necessary in order to obtain more clear evidence on the causal relationship since HDLI cases are being reported continuously.

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References (49)

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Aerts O / 2017 / Contact allergy caused by isothiazolinone derivatives : an overview of non-cosmetic and unusual cosmetic sources / Euro J Dermatol 27(2):115~122 google schola Bohn S / 2000 / Airborne contact dermatitis from methylchloroisothiazolinone in wall paint. Abolition of symptoms by chemical allergen inactivation / Contact Derm 42(4):196~201 google schola European Chemicals Agency / Substance Infocard google schola Special Committee for Examining the Cause of Tragedy caused by Humidifier Disinfectant (SCECTHD) / 2020 / Analysis of components of disinfectant contained in humidifier disinfectant products google schola European Commission / COMMISSION REGULATION (EU) No 1003/2014 of 18 September 2014amending Annex V to Regulation (EC) No 1223/2009 of the European Parliament and of the Council on Cosmetic Products Off J Eur Union google schola

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