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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 468 - 479 (12page)
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Objectives: Recently, a report was published that the humidifier disinfectant CMIT/MIT did not cause developmental toxicity and was not detected in systemic circulation as a result of an inhalation toxicity test. Therefore, this study was carried out to investigate any associations between CMIT/MIT exposure and developmental toxicity using the in vivo apical toxicity test method. Methods: Groups of pregnant C57BL/6 mice were instilled in the trachea with chloromethylisothiazolinone/ methylisothiazolinone (CMIT/MIT) using a visual instillobot over a period of seven days from days 11 to 17 days post-coitum. For the in vivo apical toxicity test method, an LD50-based dose-range finding model was applied to decide the dose range for inducing developmental toxicity. Results: Among the groups of 0, 0.1, 0.5, 1.0, and 1.5 mg ai/kg/day CMIT/MIT, the exposure groups of 0.5 mg and 1.0 ai/kg/day CMIT/MIT were estimated to reflect the thresholds for the stillbirth and death of pregnant mice, respectively. The groups of 0.5, 1.0, and 1.5 mg ai/kg/day CMIT/MIT induced stillbirth rates of 2.57, 10, and 53.8%, respectively. Another exposure group of 0.75 mg ai/kg/day CMIT/MIT did not induce any deaths of pregnant mice and resulted in a stillbirth rate of 8% in only one of six pregnant mice. Conclusions: CMIT/MIT can induce stillbirth in pregnant mice. It was also concluded that CMIT/MIT moves through the pulmonary circulation system and then continues on through systemic circulation and the placenta. There is a possibility of stillbirth and other health causalities in humans beyond the lungs caused by CMIT/MIT exposure.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Park DU / 2017 / Types of householdhumidifier disinfectant and associated risk of lung injury (HDLI) in South Korea / Sci Total Environ 596-597:53~60
Asian Citizen's Center for Environment. / Humidifier disinfectant manufacturer Prosecutor recall and report center installation request
김하영 / 2017 / 마우스의 기도 내 점적을 통한 가습기살균제 CMIT/MIT와 사망 간의 원인적 연관성에 관한 연구 / 한국환경보건학회지 43(4):247~256
Park YC / 2010 / The molecular and biochemical principles of toxicology / Korean studies Information Publishing Company Press
Williams TM / 2007 / The mechanism of action of isothiazolone biocides / Power Plant Chemistry 9(1):14~22
Asian Citizen's Center for Environment. / Humidifier disinfectant manufacturer Prosecutor recall and report center installation request
김하영 / 2017 / 마우스의 기도 내 점적을 통한 가습기살균제 CMIT/MIT와 사망 간의 원인적 연관성에 관한 연구 / 한국환경보건학회지 43(4):247~256
Park YC / 2010 / The molecular and biochemical principles of toxicology / Korean studies Information Publishing Company Press
Williams TM / 2007 / The mechanism of action of isothiazolone biocides / Power Plant Chemistry 9(1):14~22
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Review of Inhalation Health Risks Involving Chloromethylisothiazolinone (CMIT) and Methylisothiazolinone (MIT) Used as Disinfectants in Household Humidifiers
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The chemical mixture of CMIT and MIT induces mouse type II epithelial cell damage and inflammatory responses in vivo
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Effect of animal strain and exposure route on chloromethylisothiazolinone and methylisothiazolinone(CMIT/MIT)-induced lung injury
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A study on the mechanism of chloromethylisothiazolinone and methylisothiazolinone(CMIT/MIT)-induced lung injury using in vitro and in vivo systems
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Comparison of the toxic effects of chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) on the respiratory system in mice
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Functional and dynamic mitochondrial damage by chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) mixture in brain endothelial cell lines and rat cerebrovascular endothelium
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Effects of Stabilizer Magnesium nitrate on CMIT/MIT-induced Respiratory Toxicity
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CMIT/MIT 가습기살균제 사용에 따른 피해구제 신청자의 노출등급 및 노출특성 분석
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Species and strain differences on toxic response to biocide, CMIT/MIT exposure in Daphnia sp . : Epigenetics and Proteomics analysis
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