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논문 기본 정보

자료유형
학술저널
저자정보
Kim Jiwon (Department of Environmental Health Korea National Open University Seoul Korea.Department of Anthrop) Park Soyoung (Department of Occupational and Environmental Medicine Kangbuk Samsung Hospital Sungkyunkwan Univers) Zoh Kyung Ehi (Department of Environmental Health Sciences Graduate School of Public Health Seoul National Univers) Park Jihoon (Chemical Safety Management Department Nakdong River Basin Environmental Office Ministry of Environm) Choi Sangjun (Graduate School of Public Health and Healthcare Management The Catholic University of Korea Seoul K) Hwang Sung Ho (National Cancer Control Institute National Cancer Center Goyang Korea.) Lee So-Yeon (Department of Pediatrics Childhood Asthma and Atopy Center Humidifier Disinfectant Health Center As) Park Dong-Uk (Department of Environmental Health Korea National Open University Seoul Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.37 No.13
발행연도
2022.4
수록면
1 - 10 (10page)
DOI
10.3346/jkms.2022.37.e101

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초록· 키워드

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The association between lung injury and exposure to humidifier disinfectant (HD) containing a mixture of chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) has been controversial in South Korea. This study conducts a literature review in order to evaluate the likelihood of CMIT/MIT reaching the lower part of the respiratory tract and causing lung injury. A literature review focused on the inhalation risk of HD containing a mixture of CMIT and MIT. The major contents included the physicochemical properties of CMIT and MIT contained in HDs and methodological reviews on substance analysis, toxicity tests and clinical cases. HD products marketed in South Korea have been reported to contain approximately 1?2% CMIT and 0.2?0.6% MIT along with magnesium nitrate (20?25%), magnesium chloride (0.2?1.0%), and water (70?75%). The types of CMIT and MIT dispersed into the air and deposited in the respiratory tract are assumed to be either gaseous substances or nanoparticles mixed with magnesium salts. The result of the literature review including clinical cases of lung injury among CMIT/MIT HD product users, demonstrated that these chemicals likely reach the lower respiratory tract and accordingly cause lung injury. A number of humidifier disinfectant-associated lung injury cases with clinical evidence should be prioritized in risk assessment of HD containing CMIT and MIT, even though there might be insufficient evidence in all related areas, including inhalation exposure assessment studies, animal testing, and epidemiological studies.

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