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- 학술저널
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- 2020.1
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Background: Studies in experimental models of allergic asthma have shown that mesenchymal stem cells (MSCs) have therapeutic potential for T-helper 2 (TH2) cell-mediated inflammation. However, the mechanisms underlying these therapeutic effects are not fully understood and their safety has not been confirmed. Methods: Using a mouse model of experimental allergic asthma, we investigated the efficacy of human adipose-derived mesenchymal stem cells (hADSCs) or human bone marrow- derived mesenchymal stem cells (hBMSCs) according to treatment frequency and timing. Results: Ovalbumin (OVA)-sensitized and -challenged mice exhibited airway hyperresponsiveness (AHR), airway inflammation, and significant increases in TH2 cytokine levels. Both double and single human mesenchymal stem cell (hMSC) treatments significantly decreased AHR and bronchoalveolar lavage fluid counts. In addition, single treatment with hMSCs showed significant attenuation of allergic airway inflammation. However, double treatment with hMSCs during OVA -sensitization and -challenge further increased inflammatory cell infiltration, and TH2 cytokine levels. Conclusion: The results of treatment with hADSCs or hBMSCs suppresses AHR and airway inflammation. However, double hMSC treatment significantly induces eosinophilic airway inflammation and lung histological changes. Therefore, double hMSC treatment is ineffective against asthma and single injection frequency appears to be more important for the treatment of asthma. These results suggest that hMSC therapy can be used for treatment of asthma patients but that it should be used carefully.
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참고문헌 (51)
참고문헌 신청
Olin JT / 2014 / Asthma: pathogenesis and novel drugs for treatment / BMJ 349:g5517
Holgate ST / 2009 / A new look at the pathogenesis of asthma / Clin Sci(Lond) 118(7):439~450
Saglani S / 2015 / Novel concepts in airway inflammation and remodelling in asthma / Eur Respir J 46(6):1796~1804
Barnes PJ / 1997 / Current therapies for asthma. Promise and limitations / Chest 111(2 Suppl):17S~26S
Riccioni G / 2004 / Review: Pharmacological treatment of airway remodeling: inhaled corticosteroids or antileukotrienes? / Ann Clin Lab Sci 34(2):138~142
Holgate ST / 2009 / A new look at the pathogenesis of asthma / Clin Sci(Lond) 118(7):439~450
Saglani S / 2015 / Novel concepts in airway inflammation and remodelling in asthma / Eur Respir J 46(6):1796~1804
Barnes PJ / 1997 / Current therapies for asthma. Promise and limitations / Chest 111(2 Suppl):17S~26S
Riccioni G / 2004 / Review: Pharmacological treatment of airway remodeling: inhaled corticosteroids or antileukotrienes? / Ann Clin Lab Sci 34(2):138~142
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