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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Chung, Daeyeong (Department of Neurosurgery, Cham Teun Teun Hospital) Cho, Dae-Chul (Department of Neurosurgery, Kyungpook National University Hospital) Park, Seong-Hyun (Department of Neurosurgery, Kyungpook National University Hospital) Kim, Kyoung-Tae (Department of Neurosurgery, Kyungpook National University Hospital) Sung, Joo-Kyung (Department of Neurosurgery, Kyungpook National University Hospital) Jeon, Younghoon (Department of Anesthesiology and Pain Medicine, School of Dentistry, Kyungpook National University)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제61권 제2호
발행연도
2018.1
수록면
186 - 193 (8page)

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Objective : The purpose of this study was to evaluate pain-related behaviors after bilateral C2 root resection and change in pain patterns in the suboccipital region in rats. Methods : Male Sprague-Dawley rats were randomly assigned to three groups (n=25/group); $n{\ddot{a}}ive$, sham, and C2 resection. Three, 7, 10, and 14 days after surgery, cold allodynia was assessed using $20{\mu}L$ of 99.7% acetone. c-Fos and c-Jun were immunohistochemically stained to evaluate activation of dorsal horn gray matter in C2 segments of the spinal cord 2 hours, 1 day, 7 days, and 14 days after surgery. Results : Three days after surgery, the response to acetone in the sham group was significantly greater than in the $n{\ddot{a}}ive$ group, and this significant difference between the $n{\ddot{a}}ive$ and sham groups was maintained throughout the experimental period (p<0.05 at 3, 7, 10, and 14 days). Seven, 10, and 14 days after surgery, the C2 root resection group exhibited a significantly greater response to acetone than the $n{\ddot{a}}ive$ group (p<0.05), and both the sham and C2 resection groups exhibited significantly greater responses to acetone compared with 3 days after surgery. No significant difference in cold allodynia was observed between the sham and C2 root resection groups throughout the experimental period. Two hours after surgery, both the sham and C2 root resection groups exhibited significant increases in c-Fos- and c-Jun-positive neurons compared with the naive group (p=0.0021 and p=0.0358 for the sham group, and p=0.0135 and p=0.014 for the C2 root resection group, respectively). One day after surgery, both the sham and C2 root resection groups exhibited significant decreases in c-Fos -positive neurons compared with two hours after surgery (p=0.0169 and p=0.0123, respectively), and these significant decreases in c-Fos immunoreactivity were maintained in both the sham and C2 root resection groups 7 and 14 days after surgery. The sham and C2 root resection groups presented a tendency toward a decrease in c-Jun-positive neurons 1, 7, and 14 days after surgery, but the decrease did not reach statistical significance. Conclusion : We found no significant difference in cold allodynia and the early expression of c-Fos and c-Jun between the sham and C2 resection groups. Our results may support the routine resection of the C2 nerve root for posterior C1-2 fusion, but, further studies are needed.
#Cold allodynia #C2 root resection #Neuropathic pain #Posterior atlantoaxial fusion

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참고문헌 (32)

참고문헌 신청
Ahn DK / 2009 / Compression of the trigeminal ganglion produces prolonged nociceptive behavior in rats / Eur J Pain 13:568~575 Crossref Berrocal YA / 2007 / Increased spinal c-Fos expression with noxious and non-noxious peripheral stimulation after severe spinal contusion / Neurosci Lett 413:58~62 Crossref Broude E / 1997 / c-Jun expression in adult rat dorsal root ganglion neurons, differential response after central or peripheral axotomy / Exp Neurol 148:367~377 Crossref Campbell JN / 2006 / Mechanism of neuropathic pain / Neuron 52:77~92 Crossref Catheline G / 1999 / Are there long-term changes in the basal or evoked Fos expression in the dorsal horn of the spinal cord of the mononeuropathic rat? / Pain 80:347~357 Crossref

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