Neuronal Signatures of Negative and Positive Schemas towards the Self and Others in Patients with Early Stage Schizophrenia

Jie Shen; Guangfan Shen; Kim Woo-Sung; Uyanga Tsogt; Congcong Liu; Jing Sui; Chung Young-Chul

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자료유형: 학술저널

저자정보: Jie Shen (Department of Psychiatry Jeonbuk National University Medical School) Guangfan Shen (Department of Psychiatry Jeonbuk National University Medical School) Kim Woo-Sung (Department of Psychiatry Jeonbuk National University Medical School) Uyanga Tsogt (Department of Psychiatry Jeonbuk National University Medical School) Congcong Liu (Department of Psychiatry Jeonbuk National University Medical School) Jing Sui (Brainnetome Center and National Laboratory of Pattern Recognition Institute of Automation Chinese A) Chung Young-Chul (Department of Psychiatry Jeonbuk National University Medical School)

저널정보: 대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제18권 제4호

발행연도: 2021.1

수록면: 284 - 294 (11page)

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Objective The present study investigated the functional neuroanatomy underlying negative and positive schemas towards the self and others in patients with early stage schizophrenia spectrum disorders (SSDs) using a task-based fMRI procedure.Methods This study included 50 patients with SSDs and 52 controls. The schema-evoking task consisted of four active conditions and neutral condition. Differences in brain activation were compared between the two groups. Correlation analysis was performed between task-related activation and psychopathology.Results The SSD patients exhibited higher activity of the left middle and inferior frontal gyri under the negative-others minus neutral contrast as well as greater activation of the left superior and middle frontal gyri and right medial superior frontal gyrus under the positive- self minus neutral and positive-others minus neutral contrasts. Under the positive-others minus neutral contrast, negative correlation was observed between activity of the right inferior parietal gyrus and right angular and total score of the Positive and Negative Syndrome Scale (PANSS), whereas positive correlation between activity of the left middle cingulate gyrus and left/right precuneus and positive-others score of the Brief Core Schema Scales (BCSS).Conclusion The present findings suggest that the frontal brain regions of SSD patients are more sensitive to negative and positive schemas towards the self and/or others compared to those of controls.

#Negative schema #Positive schema #Schizophrenia #fMRI.

참고문헌 (40)

참고문헌 신청

Henriksen MG / 2014 / Self-disorders and schizophrenia : a phenomenological reappraisal of poor insight and noncompliance / Schizophr Bull 40:542~547

Fowler D / 2006 / The Brief Core Schema Scales(BCSS) : psychometric properties and associations with paranoia and grandiosity in non-clinical and psychosis samples / Psychol Med 36:749~759

Young JE / 1999 / Cognitive Therapy for Personality Disorders: A Schema-Focused Approach / Professional Resource Press

Lumley MN / 2007 / Specificity in the relations among childhood adversity, early maladaptive schemas, and symptom profiles in adolescent depression / Cogn Ther Res 31:639~657

Balsamo M / 2015 / The mediating role of early maladaptive schemas in the relation between corumination and depression in young adults / PLoS One 10:e0140177

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