지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 55 - 63 (9page)
이용수
초록· 키워드
오류제보하기
ObjectiveThis study aimed to investigate the potential predictive factors for platinum resistance and poor prognosis inepithelial ovarian, fallopian tube, and primary peritoneal cancer treated with platinum-based chemotherapy. MethodsMedical records of 306 patients with the above mentioned cancers treated with platinum-based chemotherapybetween 2007 and 2017 were retrospective reviewed. Clinical data, preoperative neutrophil-to-lymphocyte ratio (NLR),platelet-to-lymphocyte ratio (PLR), platinum-free interval, and survival time were recorded. NLR, PLR, and cancerantigen 125 (CA125) levels were calculated for an optimal cutoff point using receiver operating characteristic curves. The clinicopathological variables were compared using univariate and multivariate analyses to identify independentpredictive factors for platinum resistance and poor survival outcomes. ResultsThe optimal cutoff points for NLR, PLR, and CA125 were 3.38, 210, and 365 IU/L, respectively. Univariate analysisindicated that NLR >3.38, PLR >210, CA125 >365, advanced stage, suboptimal disease, serous type, and ascites weresignificant predictive factors for platinum resistance. However, only NLR >3.38 and advanced stage were independentpredictive factors with an adjusted odds ratio of 1.880 and 3.333, respectively. Regarding factors associated with poorsurvival outcomes, only PLR >210 and advanced stage were independent factors, with a hazard ratio of 1.578 and 3.994,respectively. ConclusionHigh NLR and advanced stage were potential independent predictive factors for platinum resistance, whereas highPLR and advanced stage were potential independent predictive factors for poor survival outcomes.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
International Agency for Research on Cancer / Estimated number of new cases in 2018, worldwide, females
Jayson GC / 2014 / Ovarian cancer / Lancet 384:1376~1388
Pignata S / 2017 / Treatment of recurrent ovarian cancer / Ann Oncol 28:viii51~6
Ocana A / 2017 / Neutrophils in cancer : prognostic role and therapeutic strategies / Mol Cancer 16:137~144
Badora-Rybicka A / 2016 / Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio before chemotherapy as potential prognostic factors in patients with newly diagnosed epithelial ovarian cancer / ESMO Open 1:e000039
Jayson GC / 2014 / Ovarian cancer / Lancet 384:1376~1388
Pignata S / 2017 / Treatment of recurrent ovarian cancer / Ann Oncol 28:viii51~6
Ocana A / 2017 / Neutrophils in cancer : prognostic role and therapeutic strategies / Mol Cancer 16:137~144
Badora-Rybicka A / 2016 / Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio before chemotherapy as potential prognostic factors in patients with newly diagnosed epithelial ovarian cancer / ESMO Open 1:e000039
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Investigating Preoperative Hematologic Markers for Prediction of Ovarian Cancer Surgical Outcome
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Identifying the role of neutrophil-to-lymphocyte ratio and platelets-to-lymphocyte ratio as prognostic markers in patients undergoing resection of pancreatic ductal adenocarcinoma
Annals of Hepato-Biliary-Pancreatic Surgery
2018 .08
-
The Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Are Prognostic Factors in Patients with Locally Advanced Pancreatic Cancer Treated with Chemoradiotherapy
Gut and Liver
2018 .01
-
Clinical Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Acute Unilateral Vestibulopathy
Journal of Clinical Neurology
2024 .05
-
Association of the Preoperative Neutrophil-to-Lymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer
Endocrinology and Metabolism
2015 .01
-
류마티스관절염 활성도와 호중구-림프구 비, 혈소판-림프구 비의 상관관계
대한류마티스학회지
2016 .01
-
Serum lactate dehydrogenase is a possible predictor of platinum resistance in ovarian cancer
Obstetrics & Gynecology Science
2020 .01
-
The Relationship of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio with Bone Mineral Density in Korean Postmenopausal Women
전남의대학술지
2019 .01
-
Prognostic Significance of Retroperitoneal Lymphadenectomy, Preoperative Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Primary Fallopian Tube Carcinoma: A Multicenter Study
Cancer Research and Treatment
2015 .01
-
Systemic Inflammatory Response Markers and CA-125 Levels in Ovarian Clear Cell Carcinoma: A Two Center Cohort Study
Cancer Research and Treatment
2016 .01
-
Underlying liver disease and advanced stage liver cancer are associated with elevated neutrophil-lymphocyte ratio
Clinical and Molecular Hepatology
2019 .01
-
Preoperative neutrophil-to-lymphocyte ratio is a prognostic factor for overall survival in patients with gastric cancer
Annals of Surgical Treatment and Research
2015 .07
-
In which group of gastric cancer patients is the preoperative neutrophil-to-lymphocyte ratio a significant prognostic factor?
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2016 .06
-
Do changes in inflammatory markers predict hepatocellular carcinoma recurrence and survival after liver transplantation?
Annals of Hepato-Biliary-Pancreatic Surgery
2022 .02
-
돌발성 난청의 예후 예측 인자로서 호중구-림프구 비율 및 혈소판-림프구 비율의 의미
대한이비인후-두경부외과학회지
2018 .01
-
Association between the Neutrophil-to-lymphocyte Ratio, and Platelet-to-lymphocyte Ratio and Rheumatoid Arthritis and their Correlations with the Disease Activity: A Meta-analysis
대한류마티스학회지
2018 .01
-
Pretreatment neutrophil-to-lymphocyte ratio and its dynamic change during neoadjuvant chemotherapy as poor prognostic factors in advanced ovarian cancer
Obstetrics & Gynecology Science
2018 .01
-
Preoperative Neutrophil to Lymphocyte Ratio as a Prognostic Factor in Patients with Non-metastatic Renal Cell Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Prognostic Value of Baseline Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios in Local and Advanced Gastric Cancer Patients
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Preoperative neutrophil-lymphocyte ratio and CEA is associated with poor prognosis in patients with synchronous colorectal cancer liver metastasis
Annals of Surgical Treatment and Research
2019 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0