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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 227 - 234 (8page)
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ObjectiveThe purpose of this study was to determine the prognostic implications of the pretreatment neutrophil-to-lymphocyteratio (NLR) and its dynamic change during chemotherapy in patients with advanced epithelial ovarian cancerundergoing neoadjuvant chemotherapy. MethodsWe performed a retrospective analysis of 203 patients who underwent neoadjuvant chemotherapy prior to intervaldebulking surgery for advanced-stage ovarian cancer at Yonsei Cancer Hospital between 2007 and 2015. PretreatmentNLR was evaluated before starting neoadjuvant chemotherapy. Change in NLR was defined as the post-neoadjuvantNLR value divided by the initial value. The correlation of NLR and its dynamic change with chemotherapy responsescore, response rate, and recurrence was analyzed. ResultsThe NLR ranged from 0.64 to 22.8. In univariate analyses, a higher pretreatment NLR (>3.81) was associated with pooroverall survival (OS), but not progression-free survival (PFS). Through multivariate analysis, high pretreatment NLR wasshown to be an independent parameter affecting OS, but not necessarily PFS. Changes in NLR during chemotherapywere better predictors of PFS than baseline NLR. Patients with increased NLR during chemotherapy showedsignificantly poor PFS, and this change was an independent predictor of PFS. ConclusionPretreatment NLR and its dynamic change during chemotherapy may be important prognostic factors in patients whoundergo neoadjuvant chemotherapy.
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참고문헌 (30)
참고문헌 신청
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108
이정윤 / 2014 / Trends in gynecologic cancer mortality in East Asian regions / Journal of Gynecologic Oncology 25(3):174~182
임명철 / 2013 / Incidence of cervical, endometrial, and ovarian cancer in Korea, 1999-2010 / Journal of Gynecologic Oncology 24(4):298~302
National Comprehensive Cancer Network / Clinical practice guidelines in oncology
Greimel E / 2013 / Quality of life of advanced ovarian cancer patients in the randomized phase III study comparing primary debulking surgery versus neo-adjuvant chemotherapy / Gynecol Oncol 131:437~444
이정윤 / 2014 / Trends in gynecologic cancer mortality in East Asian regions / Journal of Gynecologic Oncology 25(3):174~182
임명철 / 2013 / Incidence of cervical, endometrial, and ovarian cancer in Korea, 1999-2010 / Journal of Gynecologic Oncology 24(4):298~302
National Comprehensive Cancer Network / Clinical practice guidelines in oncology
Greimel E / 2013 / Quality of life of advanced ovarian cancer patients in the randomized phase III study comparing primary debulking surgery versus neo-adjuvant chemotherapy / Gynecol Oncol 131:437~444
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