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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 250 - 258 (9page)
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Purpose We compared the predictive and prognostic values of leukocyte differential counts, systemic inflammatory (SIR) markers and cancer antigen 125 (CA-125) levels, and identified the most useful marker in patients with ovarian clear cell carcinoma (OCCC).
Materials and Methods The study included 109 patients with OCCC who did not have any inflammatory conditions except endometriosis, and underwent primary debulking surgery between 1997 and 2012. Leukocyte differential counts (neutrophil, lymphocyte, monocyte, eosinophil, basophil, and platelet), SIR markers including neutrophil to lymphocyte ratio (NLR), monocyte to lympho- cyte ratio (MLR), and platelet to lymphocyte ratio (PLR), and CA-125 levels were estimated to select potential markers for clinical outcomes.
Results Among potential markers (neutrophil, monocyte, platelet, NLR, MLR, PLR, and CA-125 levels) selected by stepwise comparison, CA-125 levels were best at predicting advanced stage disease, suboptimal debulking and platinum-resistance (cut-off values, ! 46.5, ! 11.45, and ! 66.4 U/mL; accuracies, 69.4%, 78.7%, and 68.5%) while PLR ! 205.4 predicted non- complete response (CR; accuracy, 71.6%) most accurately. Moreover, PLR < 205.4 was an independent factor for the reduced risk of non-CR (adjusted odds ratio, 0.17; 95% confi- dence interval [CI], 0.04 to 0.69), and NLR < 2.8 was a favorable factor for improved progression-free survival (PFS; adjusted hazard ratio, 0.49; 95% CI, 0.25 to 0.99) despite lack of a marker for overall survival among the potential markers.
Conclusion CA-125 levels may be the most useful marker for predicting advanced-stage disease. Suboptimal debulking and platinum-resistance, and PLR and NLR may be most effective to predict non-CR and PFS in patients with OCCC.
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참고문헌 (25)
참고문헌 신청
서동훈 / 2014 / Major clinical research advances in gynecologic cancer in 2013 / Journal of Gynecologic Oncology 25(3):236~248
김장흡 / 2014 / Müllerian inhibiting substance/anti-Müllerian hormone: A novel treatment for gynecologic tumors / Obstetrics & Gynecology Science 57(05):343~357
Rustin GJ / 2011 / Definitions for response and progression in ovarian cancer clinical trials incorporating RECIST 1.1 and CA 125 agreed by the Gynecological Cancer Intergroup (GCIG) / Int J Gynecol Cancer 21:419~423
Tian C / 2009 / CA-125 change after chemotherapy in prediction of treatment outcome among advanced mucinous and clear cell epithelial ovarian cancers : a Gynecologic Oncology Group study / Cancer 115:1395~1403
Eltabbakh GH / 2006 / Clinical and molecular differences between clear cell and papillary serous ovarian carcinoma / J Surg Oncol 93:379~386
김장흡 / 2014 / Müllerian inhibiting substance/anti-Müllerian hormone: A novel treatment for gynecologic tumors / Obstetrics & Gynecology Science 57(05):343~357
Rustin GJ / 2011 / Definitions for response and progression in ovarian cancer clinical trials incorporating RECIST 1.1 and CA 125 agreed by the Gynecological Cancer Intergroup (GCIG) / Int J Gynecol Cancer 21:419~423
Tian C / 2009 / CA-125 change after chemotherapy in prediction of treatment outcome among advanced mucinous and clear cell epithelial ovarian cancers : a Gynecologic Oncology Group study / Cancer 115:1395~1403
Eltabbakh GH / 2006 / Clinical and molecular differences between clear cell and papillary serous ovarian carcinoma / J Surg Oncol 93:379~386
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