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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제2호
- 발행연도
- 2020.1
- 수록면
- 279 - 286 (8page)
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A novel compound named ‘kanakugiol’ was recently isolated from Lindera erythrocarpa and showed free radical-scavenging and antifungal activities. However, the details of the anticancer effect of kanakugiol on breast cancer cells remain unclear. We investigated the effect of kanakugiol on the growth of MCF-7 human breast cancer cells. Kanakugiol affected cell cycle progression, and decreased cell viability in MCF-7 cells in a dose-dependent manner. It also enhanced PARP cleavage (50 kDa), whereas DNA laddering was not induced. FACS analysis with annexin V-FITC/PI staining showed necrosis induction in kanakugiol-treated cells. Caspase-9 cleavage was also induced. Expression of death receptors was not altered. However, Bcl-2 expression was suppressed, and mitochondrial membrane potential collapsed, indicating limited apoptosis induction by kanakugiol. Immunofluorescence analysis using α- tubulin staining revealed mitotic exit without cytokinesis (4N cells with two nuclei) due to kanakugiol treatment, suggesting that mitotic catastrophe may have been induced via microtubule destabilization. Furthermore, cell cycle analysis results also indicated mitotic catastrophe after cell cycle arrest in MCF-7 cells due to kanakugiol treatment. These findings suggest that kanakugiol inhibits cell proliferation and promotes cell death by inducing mitotic catastrophe after cell cycle arrest. Thus, kanakugiol shows potential for use as a drug in the treatment of human breast cancer.
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참고문헌 (30)
참고문헌 신청
Santi Phosri / 2018 / Siamese Crocodile White Blood Cell Extract Inhibits Cell Proliferation and Promotes Autophagy in Multiple Cancer Cell Lines / Journal of Microbiology and Biotechnology 28(6):1007~1021
Holland AJ / 2012 / Losing balance : the origin and impact of aneuploidy in cancer / EMBO Rep 13:501~514
Gordon DJ / 2012 / Causes and consequences of aneuploidy in cancer / Nat. Rev. Genet 13:189~203
Boveri T / 2008 / Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris / J. Cell Sci. 121(Suppl 1):1~84
윤재환 / 2020 / Methyl Linderone Suppresses TPA-Stimulated IL-8 and MMP-9 Expression Via the ERK/STAT3 Pathway in MCF-7 Breast Cancer Cells / Journal of Microbiology and Biotechnology 30(3):325~332
Holland AJ / 2012 / Losing balance : the origin and impact of aneuploidy in cancer / EMBO Rep 13:501~514
Gordon DJ / 2012 / Causes and consequences of aneuploidy in cancer / Nat. Rev. Genet 13:189~203
Boveri T / 2008 / Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris / J. Cell Sci. 121(Suppl 1):1~84
윤재환 / 2020 / Methyl Linderone Suppresses TPA-Stimulated IL-8 and MMP-9 Expression Via the ERK/STAT3 Pathway in MCF-7 Breast Cancer Cells / Journal of Microbiology and Biotechnology 30(3):325~332
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