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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 203 - 214 (12page)
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Post-translational modifications play major roles in the stability, function, and localization of target proteins involved in the nervous system. The ubiquitin-proteasome pathway uses small ubiquitin molecules to degrade neuronal proteins. Deubiquitinating enzymes (DUBs) reverse this degradation and thereby control neuronal cell fate, synaptic plasticity, axonal growth, and proper function of the nervous system. Moreover, mutations or downregulation of certain DUBs have been found in several neurodegenerative diseases, as well as gliomas and neuroblastomas. Based on emerging findings, DUBs represent an important target for therapeutic intervention in various neurological disorders. Here, we summarize advances in our understanding of the roles of DUBs related to neurobiology.
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참고문헌 (118)
참고문헌 신청
Abbracchio, M. P. / 1999 / Brain adenosine receptors as targets for therapeutic intervention in neurodegenerative diseases / Ann. N. Y. Acad. Sci 890:79~92
Abdul Rehman, S. A. / 2016 / MINDY-1 is a member of an evolutionarily conserved and structurally distinct new family of deubiquitinating enzymes / Mol. Cell 63:146~155
Alexopoulou, Z. / 2016 / Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease / Proc. Natl. Acad. Sci. U. S. A 113:E4688~E4697
Anderson, C. / 2005 / Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice / J. Neurochem 95:724~731
Anggono, V. / 2012 / Regulation of AMPA receptor trafficking and synaptic plasticity / Curr. Opin. Neurobiol 22:461~469
Abdul Rehman, S. A. / 2016 / MINDY-1 is a member of an evolutionarily conserved and structurally distinct new family of deubiquitinating enzymes / Mol. Cell 63:146~155
Alexopoulou, Z. / 2016 / Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease / Proc. Natl. Acad. Sci. U. S. A 113:E4688~E4697
Anderson, C. / 2005 / Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice / J. Neurochem 95:724~731
Anggono, V. / 2012 / Regulation of AMPA receptor trafficking and synaptic plasticity / Curr. Opin. Neurobiol 22:461~469
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