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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 828 - 835 (8page)
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PIWI Argonaute proteins and Piwi-interacting RNAs (piRNAs) are expressed in all animal species and play a critical role in cellular defense by inhibiting the activation of transposable elements in the germline. Recently, new evidence suggests that PIWI proteins and piRNAs also play important roles in various somatic tissues, including neurons. This review summarizes the neuronal functions of the PIWI-piRNA pathway in multiple animal species, including their involvement in axon regeneration, behavior, memory formation, and transgenerational epigenetic inheritance of adaptive memory. This review also discusses the consequences of dysregulation of neuronal PIWI-piRNA pathways in certain neurological disorders, including neurodevelopmental and neurodegenerative diseases. A full understanding of neuronal PIWI-piRNA pathways will ultimately provide novel insights into small RNA biology and could potentially provide precise targets for therapeutic applications.
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등록된 정보가 없습니다.
참고문헌 (98)
참고문헌 신청
H. Y. / 1999 / Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 / Nat. Genet 23:185~188
Amir, R. E. / 2000 / Rett syndrome : methyl-CpG-binding protein 2 mutations and phenotype-genotype correlations / Am. J. Med. Genet 97:147~152
Aravin, A. / 2006 / A novel class of small RNAs bind to MILI protein in mouse testes / Nature 442:203~207
Aravin, A. A. / 2008 / A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice / Mol. Cell 31:785~799
Ashe, A. / 2012 / piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans / Cell 150:88~99
Amir, R. E. / 2000 / Rett syndrome : methyl-CpG-binding protein 2 mutations and phenotype-genotype correlations / Am. J. Med. Genet 97:147~152
Aravin, A. / 2006 / A novel class of small RNAs bind to MILI protein in mouse testes / Nature 442:203~207
Aravin, A. A. / 2008 / A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice / Mol. Cell 31:785~799
Ashe, A. / 2012 / piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans / Cell 150:88~99
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