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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 248 - 253 (6page)
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Gene expression in HIV-1 is regulated by the promoters in 5’ long-terminal repeat (LTR) element, which contain multiple DNA regulatory elements that serve as binding sites for cellular transcription factors. YY1 could repress HIV-1 gene expression and latent infection. Here, however, we observed that virus production can be increased by YY1 over-expression and decreased under YY1 depleted condition by siRNA treatment. To identify functional domain(s) of YY1 activation, we constructed a number of YY1 truncated mutants. Our data show that full-length YY1 enhances the viral transcription both through U3 and U3RU5 promoters. Moreover, the C-terminal region (296-414 residues) of YY1 is responsible for the transcriptional upregulation, which could be enhanced further in the presence of the viral Tat protein. The central domain of YY1 (155-295 residues) does not affect LTR activity but has a negative effect on HIV-1 gene expression. Taken together, our study shows that YY1 could act as a transcriptional activator in HIV-1 replication, at least in the early stages of infection.
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참고문헌 (31)
참고문헌 신청
Atchison L / 2003 / Transcription factor YY1 functions as a PcG protein in vivo / EMBO J 22:1347~1358
Bushmeyer S / 1995 / Characterization of functional domains within the multifunctional transcription factor, YY1 / J Biol Chem 270:30213~30220
Austen M / 1997 / Characterization of the transcriptional regulator YY1. The bipartite transactivation domain is independent of interaction with the TATA box-binding protein, transcription factor IIB, TAFII55, or cAMP-responsive element-binding protein(CPB)-binding protein / J Biol Chem 272:1709~1717
Wilkinson FH / 2006 / Polycomb recruitment to DNA in vivo by the YY1 REPO domain / Proc Natl Acad Sci U S A 103:19296~19301
Shi Y / 1991 / Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein / Cell 67:377~388
Bushmeyer S / 1995 / Characterization of functional domains within the multifunctional transcription factor, YY1 / J Biol Chem 270:30213~30220
Austen M / 1997 / Characterization of the transcriptional regulator YY1. The bipartite transactivation domain is independent of interaction with the TATA box-binding protein, transcription factor IIB, TAFII55, or cAMP-responsive element-binding protein(CPB)-binding protein / J Biol Chem 272:1709~1717
Wilkinson FH / 2006 / Polycomb recruitment to DNA in vivo by the YY1 REPO domain / Proc Natl Acad Sci U S A 103:19296~19301
Shi Y / 1991 / Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein / Cell 67:377~388
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