지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 15 (15page)
이용수
초록· 키워드
오류제보하기
Deubiquitinases (DUBs) and noncoding RNAs have been the subjects of recent extensive studies regarding their roles in lung cancer, but the mechanisms involved are largely unknown. In our study, we used The Cancer Genome Atlas data set and bioinformatics analyses and identified USP21, a DUB, as a potential contributor to oncogenesis in nonsmall-cell lung cancer (NSCLC). We further demonstrated that USP21 was highly expressed in NSCLCs. We then conducted a series of in vitro and in vivo assays to explore the effect of USP21 on NSCLC progression and the underlying mechanism involved. USP21 promoted NSCLC cell proliferation, migration, and invasion and in vivo tumor growth by stabilizing a well-known oncogene, Yin Yang-1 (YY1), via mediating its deubiquitination. Furthermore, YY1 transcriptionally regulates the expression of SNHG16. Moreover, StarBase bioinformatics analyses predicted that miR4500 targets SNHG16 and USP21. A series of in vitro experiments indicated that SNHG16 increased the expression of USP21 through miR-4500. In summary, the USP21/YY1/SNHG16 axis plays a role in promoting the progression of NSCLC. Therefore, the USP21/YY1/SNHG16/miR-4500 axis may be a potential therapeutic target in NSCLC treatment.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The deubiquitinase USP40 preserves endothelial integrity by targeting the heat shock protein HSP90β
Experimental and Molecular Medicine
2024 .02
-
분기기용 USP침목의 해외 적용 사례
한국철도학회 학술발표대회논문집
2024 .11
-
USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner
Experimental and Molecular Medicine
2023 .01
-
USP PC침목 분기기의 경제성(LCC) 분석
한국철도학회 학술발표대회논문집
2019 .11
-
Human transcription factor YY1 could upregulate the HIV-1 gene expression
BMB Reports
2020 .01
-
miR-638 is a new biomarker for outcome prediction of non-small cell lung cancer patients receiving chemotherapy
Experimental and Molecular Medicine
2015 .01
-
Signal Transducer and Activator of Transcription 4-Induced Up-Regulated LINC01278 Enhances Proliferation and Invasion of Non-Small Cell Lung Cancer Cells via the MicroRNA-877-5p/Activating Transcription Factor 4 Axis
조직공학과 재생의학
2024 .06
-
비 부착형 침목방진패드 적용에 따른 자갈궤도의 궤도지지강성 평가
한국도시철도학회논문집
2017 .03
-
침목패드 강성에 따른 자갈궤도 거동의 해석적 평가
한국도시철도학회논문집
2024 .12
-
Effect of USP38 C-terminal Domain and Insertion on Its Structure and Activity
한국생물공학회 학술대회
2022 .04
-
Deubiquitinase USP35 as a novel mitotic regulator via maintenance of Aurora B stability
BMB Reports
2018 .01
-
자갈도상용 USP분기기 기술 개발
한국철도학회 학술발표대회논문집
2018 .10
-
Methylation-sensitive high-resolution melting analysis of the USP44 promoter can detect early-stage hepatocellular carcinoma in blood samples
BMB Reports
2022 .11
-
Improvement of Chloride Induced Stress Corrosion Cracking Resistance of Welded 304L Stainless Steel by Ultrasonic Shot Peening
Corrosion Science and Technology
2024 .08
-
자갈궤도용 침목패드의 유럽표준 제정(안) 분석
한국철도학회 학술발표대회논문집
2015 .05
-
ER-/PR+ Breast Cancer is Controlled More Effectively with an Inflammatory Inhibitor than with the Hormonal Inhibitor
한국생물공학회 학술대회
2023 .04
-
Aldehyde dehydrogenase is used by cancer cells for energy metabolism
Experimental and Molecular Medicine
2016 .01
-
Crizotinib attenuates cancer metastasis by inhibiting TGFβ signaling in non-small cell lung cancer cells
Experimental and Molecular Medicine
2022 .08
-
MiR-34a and miR-34b/c have distinct effects on the suppression of lung adenocarcinomas
Experimental and Molecular Medicine
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0