New hydroperoxylated and 20,24-epoxylated dammarane triterpenes from the rot roots of Panax notoginseng

Jia-Huan Shang; Wen-Jie Sun; Hong-Tao Zhu; Dong Wang; Chong-Ren Yang; Ying-Jun Zhang

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자료유형: 학술저널

저자정보: Jia-Huan Shang (Chinese Academy of Sciences) Wen-Jie Sun (Chinese Academy of Sciences) Hong-Tao Zhu (Chinese Academy of Sciences) Dong Wang (Chinese Academy of Sciences) Chong-Ren Yang (Chinese Academy of Sciences) Ying-Jun Zhang (Chinese Academy of Sciences)

저널정보: 고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.44 No.3

발행연도: 2020.5

수록면: 405 - 412 (8page)

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Background: Root rot is a serious destructive disease of Panax notoginseng, a famous cultivated araliaceous herb called Sanqi or Tianqi in Southwest China.
Methods: The chemical substances of Sanqi rot roots were explored by chromatographic techniques. MS, 1D/2D-NMR, and single crystal X-ray diffraction were applied to determine the structures. Murine macrophage RAW264.7 and five human cancer cell lines were used separately for evaluating the antiinflammatory and cytotoxic activities.
Results and Conclusion: Thirty dammarane-type triterpenes and saponins were isolated from the rot roots of P. notoginseng. Among them, seven triterpenes, namely, 20(S)-dammar-25-ene-24(S)-hydroperoxyl- 3b,6a,12b,20-tetrol (1), 20(S)-dammar-3-oxo-23-ene-25-hydroperoxyl-6a,12b,20-triol (2), 20(S)-dammar- 12-oxo-23-ene-25-hydroperoxyl-3b,6a,20-triol (3), 20(S)-dammar-3-oxo-23-ene-25-hydroperoxyl-12b,20- diol (4), 20(S),24(R)-epoxy-3,4-seco-dammar-25-hydroxy-12-one-3-oic acid (5), 20(S),24(R)-epoxy-3,4- seco-dammar-25-hydroxy-12-one-3-oic acid methyl ester (6), and 6a-hydroxy-22,23,24,25,26,27- hexanordammar-3,12,20-trione (7), are new compounds. In addition, 12 known ones (12e16 and 19e25) were reported in Sanqi for the first time. The new Compound 1 showed comparable antiinflammatory activity on inhibition of NO production to the positive control, whereas the known compounds 9, 12, 13, and 16 displayed moderate cytotoxicities against five human cancer cell lines. The results will provide scientific basis for understanding the chemical constituents of Sanqi rot roots and new candidates for searching antiinflammatory and antitumor agents.

#20,24-epoxylated #Dammarane-type triterpenes #Hydroperoxylated #Panax notoginseng #Inhibition of NO production

참고문헌 (35)

참고문헌 신청

Guo YX / 2003 / New progress in basic research of compound danshen dropping pills / Chin Tradit Herbal Drugs 34:U4~U5

Liu D / 1992 / Preliminary study on the photosynthetic characteristics of Panax notoginseng / South Chin J Agric Sci 5:41~43

Mao ZS / 2013 / Research progress of root rot of Panax notoginseng / Chin Med Mat 36:2051~2054

Luo WF / 1997 / On the combined infection root rot pathogens on Panax notoginseng / Acta Phytopathol Sin 27:85~91

Xia PG / 2014 / Study on chemical constituents of Panax notoginseng / Chin Tradit Herbal Drugs 45:2564~2570

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