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논문 기본 정보

자료유형
학술저널
저자정보
Valencia, Schley (Department of Neuroscience, School of Medicine, Konkuk University) Gonzales, Edson Luck (Department of Neuroscience, School of Medicine, Konkuk University) Adil, Keremkleroo Jym (Department of Neuroscience, School of Medicine, Konkuk University) Jeon, Se Jin (Center for Neuroscience, Korea Institute of Science and Technology) Kwon, Kyoung Ja (Department of Neuroscience, School of Medicine, Konkuk University) Cho, Kyu Suk (Department of Neuroscience, School of Medicine, Konkuk University) Shin, Chan Young (Department of Neuroscience, School of Medicine, Konkuk University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제27권 제4호
발행연도
2019.1
수록면
349 - 356 (8page)

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초록· 키워드

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Behavioral analysis in mice provided important contributions in helping understand and treat numerous neurobehavioral and neuropsychiatric disorders. The behavioral performance of animals and humans is widely different among individuals but the neurobehavioral mechanism of the innate difference is seldom investigated. Many neurologic conditions share comorbid symptoms that may have common pathophysiology and therapeutic strategy. The forced swim test (FST) has been commonly used to evaluate the "antidepressant" properties of drugs yet the individual difference analysis of this test was left scantly investigated along with the possible connection among other behavioral domains. This study conducted an FST-screening in outbred CD-1 male mice and segregated them into three groups: high performers (HP) or the active swimmers, middle performers (MP), and low performers (LP) or floaters. After which, a series of behavioral experiments were performed to measure their behavioral responses in the open field, elevated plus maze, Y maze, three-chamber social assay, novel object recognition, delay discounting task, and cliff avoidance reaction. The behavioral tests battery revealed that the three groups displayed seemingly correlated differences in locomotor activity and novel object recognition but not in other behaviors. This study suggests that the HP group in FST has higher locomotor activity and novelty-seeking tendencies compared to the other groups. These results may have important implications in creating behavior database in animal models that could be used for predicting interconnections of various behavioral domains, which eventually helps to understand the neurobiological mechanism controlling the behaviors in individual subjects.
#Forced swim test #Immobility #Locomotor activity #Object exploration #Novelty-seeking

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참고문헌 (35)

참고문헌 신청
Mark G. Baxter / 2010 / “I've seen it all before”: Explaining age-related impairments in object recognition. Theoretical comment on Burke et al. (2010). / Behavioral Neuroscience 124(5):706~709 Crossref Bogdanova OV / 2013 / Factors influencing behavior in the forced swim test / Physiol Behav 118:227~239 Crossref Can A / 2012 / The mouse forced swim test / J. Vis. Exp (59):3638 google schola Chen X / 2015 / Impairment of oligodendroglia maturation leads to aberrantly increased cortical glutamate and anxiety-like behaviors in juvenile mice / Front Cell Neurosci 9:467 Crossref Cloninger CR / 1986 / A unified biosocial theory of personality and its role in the development of anxiety states / Psych Dev 3:167~226 google schola

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