지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.10
- 수록면
- 684 - 691 (8page)
이용수
이 논문의 연구 히스토리 (5)
2009
Korean red ginseng intake induces gross deletions in the nef gene of HIV-1
Young Keol Cho
,
Yousun Jung
고려인삼학회 학술대회
2009.12
학술대회자료
Frequent gross deletion in the HIV-1 nef gene in hemophiliacs treated with Korean red ginseng : inhibition of detection by highly active antiretroviral therapy
Young Keol Cho
,
You Sun Jung
,
Heungsup Sung
고려인삼학회 학술대회
2009.05
학술대회자료
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Background: We have reported that defective nef and gag genes are induced in HIV-1-infected patients treated with Korean Red Ginseng (KRG).
Methods: To investigate whether KRG treatment and highly active antiretroviral therapy (HAART) affect genetic defects in the pol gene, we amplified and sequenced a partial pol gene (p-pol) containing the integrase portion (1.2 kb) by nested PCR with sequential peripheral blood mononuclear cells over 20 years and compared it with those patients at baseline, in control patients, those taking ginseng-based combination therapy (GCT; KRG plus combinational antiretroviral therapy) and HAART alone. We also compared our findings to look for the full-length pol gene (pol) (3.0-kb)
Results: Twenty-patients infected with subtype B were treated with KRG for 116±58 months in the absence of HAART. Internal deletion in the pol gene (△pol) was significantly higher in the KRG group (11.9%) than in the control group and at baseline; its detection was significantly inhibited during GCT as much as during HAART. In addition, the △pol in p-pol significantly depended on the duration of KRG treatment. In pol, the proportion of △pol was significantly higher in the KRG group (38.7%) than in the control group, and it was significantly inhibited during GCT and HAART. In contrast, the proportion of stop codon appeared not to be affected by KRG treatment. The PCR success rate was significantly decreased with longer GCT.
Conclusion: The proportion of △pol depends on template size as well as KRG treatment. HAART decreases the detection of △pol.
Methods: To investigate whether KRG treatment and highly active antiretroviral therapy (HAART) affect genetic defects in the pol gene, we amplified and sequenced a partial pol gene (p-pol) containing the integrase portion (1.2 kb) by nested PCR with sequential peripheral blood mononuclear cells over 20 years and compared it with those patients at baseline, in control patients, those taking ginseng-based combination therapy (GCT; KRG plus combinational antiretroviral therapy) and HAART alone. We also compared our findings to look for the full-length pol gene (pol) (3.0-kb)
Results: Twenty-patients infected with subtype B were treated with KRG for 116±58 months in the absence of HAART. Internal deletion in the pol gene (△pol) was significantly higher in the KRG group (11.9%) than in the control group and at baseline; its detection was significantly inhibited during GCT as much as during HAART. In addition, the △pol in p-pol significantly depended on the duration of KRG treatment. In pol, the proportion of △pol was significantly higher in the KRG group (38.7%) than in the control group, and it was significantly inhibited during GCT and HAART. In contrast, the proportion of stop codon appeared not to be affected by KRG treatment. The PCR success rate was significantly decreased with longer GCT.
Conclusion: The proportion of △pol depends on template size as well as KRG treatment. HAART decreases the detection of △pol.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects of Korean Red Ginseng combination therapy on HIV-infected patients treated with integrase strand transfer inhibitors
Journal of Ginseng Research
2024 .11
-
Trend of CD4+ Cell Counts at Diagnosis and Initiation of Highly Active Antiretroviral Therapy (HAART): Korea HIV/AIDS Cohort Study, 1992-2015
Infection and Chemotherapy
2017 .06
-
Korean Red Ginseng water extract arrests growth of xenografted lymphoma cells
Journal of Ginseng Research
2016 .10
-
Impact of HIV-1 subtypes on gross deletion in the nef gene after Korean Red Ginseng treatment
Journal of Ginseng Research
2022 .11
-
The beneficial potential of ginseng for menopause
Journal of Ginseng Research
2024 .09
-
Effect of Korean Red Ginseng extracts on drug-drug interactions
Journal of Ginseng Research
2018 .06
-
Ginseng, the natural effectual antiviral : Protective effects of Korean Red Ginseng against viral infection
Journal of Ginseng Research
2016 .10
-
Genetic defects in the nef gene are associated with Korean Red Ginseng intake : monitoring of nef sequence polymorphisms over 20 years
Journal of Ginseng Research
2017 .04
-
Immuno-enhancement effects of Korean Red Ginseng in healthy adults: a randomized, double-blind, placebo-controlled trial
Journal of Ginseng Research
2021 .01
-
Skin Disease in Korean Human Immunodeficiency Virus Patient
Annals of Dermatology
2019 .01
-
The effects of Korean Red Ginseng on stress-related neurotransmitters and gene expression: A randomized, double-blind, placebo-controlled trial
Journal of Ginseng Research
2023 .11
-
한말(1896-1897) 왕실의 홍삼 정책과 수출 연구
연세의사학
2024 .06
-
Korean Red Ginseng slows coreceptor switch in HIV-1 infected patients
Journal of Ginseng Research
2023 .01
-
Proteomic studies of putative molecular signatures for biological effects by Korean Red Ginseng
Journal of Ginseng Research
2019 .10
-
원지(遠志)가 뇌혈류 저하에 의한 흰쥐 뇌조직의 산화적 손상과 해마신경세포 자연사에 미치는 영향
대한본초학회지(본초분과학회지)
2016 .01
-
Safety and antifatigue effect of Korean Red Ginseng: a randomized, double-blind, and placebo-controlled clinical trial
Journal of Ginseng Research
2019 .10
-
Protective effects of KRG against renal injury in aged mice
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Korean Red Ginseng prevents posttraumatic stress disorder-triggered depression-like behaviors in rats via activation of the serotonergic system
Journal of Ginseng Research
2020 .07
-
Korean Red Ginseng exerts anti-inflammatory and autophagypromoting activities in aged mice
Journal of Ginseng Research
2021 .11
-
Anti-aging effects of Korean Red Ginseng (KRG) in differentiated embryo chondrocyte (DEC) knockout mice
Journal of Ginseng Research
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2020-524-000504748