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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 149 - 155 (7page)
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이 논문의 연구 히스토리 (5)
2009
Korean red ginseng intake induces gross deletions in the nef gene of HIV-1
Young Keol Cho
,
Yousun Jung
고려인삼학회 학술대회
2009.12
학술대회자료
Frequent gross deletion in the HIV-1 nef gene in hemophiliacs treated with Korean red ginseng : inhibition of detection by highly active antiretroviral therapy
Young Keol Cho
,
You Sun Jung
,
Heungsup Sung
고려인삼학회 학술대회
2009.05
학술대회자료
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Background: We have reported that internal deletions in the nef, gag, and pol genes in HIV-1-infected patients are induced in those treated with Korean Red Ginseng (KRG). KRG delays the development of resistance mutations to antiretroviral drugs.
Methods: The vif-vpr genes over 26 years in 20 hemophiliacs infected with HIV-1 from a single source were sequenced to investigate whether vif-vpr genes were affected by KRG and KRG plus highly active antiretroviral therapy (ART) (hereafter called GCT) and compared the results with our previous data.
Results: A significantly higher number of in-frame small deletions were found in the vif-vpr genes of KRG-treated patients than at the baseline, in control patients, and in ART-alone patients (p ＜ 0.001). These were significantly reduced in GCT patients (p ＜ 0.05). In contrast, sequences harboring a premature stop codon (SC) were more significant in GCT patients (10.1%) than in KRG-alone patients, control (p ＜ 0.01), and ART-alone patients (p = 0.078 for peripheral blood mononuclear cells). The proportion of SC in Vpr was similar to that in Vif, whereas the proportion of sequences revealing SC in the env-nef genes was significantly lower than that in the pol-vif-vpr genes (p ＜ 0.01). The genetic distance was 1.8 times higher in the sequences harboring SC than in the sequences without SC (p ＜ 0.001). Q135P in the vif gene is significantly associated with rapid progression to AIDS (p ＜ 0.01).
Conclusion: Our data show that KRG might induce sΔ in the vif-vpr genes and that vif-vpr genes are similarly affected by lethal mutations.
Methods: The vif-vpr genes over 26 years in 20 hemophiliacs infected with HIV-1 from a single source were sequenced to investigate whether vif-vpr genes were affected by KRG and KRG plus highly active antiretroviral therapy (ART) (hereafter called GCT) and compared the results with our previous data.
Results: A significantly higher number of in-frame small deletions were found in the vif-vpr genes of KRG-treated patients than at the baseline, in control patients, and in ART-alone patients (p ＜ 0.001). These were significantly reduced in GCT patients (p ＜ 0.05). In contrast, sequences harboring a premature stop codon (SC) were more significant in GCT patients (10.1%) than in KRG-alone patients, control (p ＜ 0.01), and ART-alone patients (p = 0.078 for peripheral blood mononuclear cells). The proportion of SC in Vpr was similar to that in Vif, whereas the proportion of sequences revealing SC in the env-nef genes was significantly lower than that in the pol-vif-vpr genes (p ＜ 0.01). The genetic distance was 1.8 times higher in the sequences harboring SC than in the sequences without SC (p ＜ 0.001). Q135P in the vif gene is significantly associated with rapid progression to AIDS (p ＜ 0.01).
Conclusion: Our data show that KRG might induce sΔ in the vif-vpr genes and that vif-vpr genes are similarly affected by lethal mutations.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (43)
참고문헌 신청
Daniels RS / 2003 / An HIV type 1 subtype B founder effect in Korea : gp160 signature patterns infer circulation of CTL-escape strains at the population level / AIDS Res Hum Retroviruses 19:631~641
Cho YK / 2019 / Genetic analysis of the full-length gag gene from the earliest Korean subclade B of HIV-1: an outbreak among Korean hemophiliacs / Viruses 11:E545
Cho YK / 2012 / Molecular evidence of HIV-1 transmission in 20 Korean individuals with haemophilia : phylogenetic analysis of the vif gene / Haemophilia 18:291~299
Cho YK / 2007 / Molecular epidemiologic study of a human immunodeficiency virus 1 outbreak in haemophiliacs B infected through clotting factor 9 after 1990 / Vox Sang 92:113~120
B.-R. Kim / 2015 / Long-term follow up of HIV-1-infected Korean haemophiliacs, after infection from a common source of virus / Haemophilia 21(1):e1~e11
Cho YK / 2019 / Genetic analysis of the full-length gag gene from the earliest Korean subclade B of HIV-1: an outbreak among Korean hemophiliacs / Viruses 11:E545
Cho YK / 2012 / Molecular evidence of HIV-1 transmission in 20 Korean individuals with haemophilia : phylogenetic analysis of the vif gene / Haemophilia 18:291~299
Cho YK / 2007 / Molecular epidemiologic study of a human immunodeficiency virus 1 outbreak in haemophiliacs B infected through clotting factor 9 after 1990 / Vox Sang 92:113~120
B.-R. Kim / 2015 / Long-term follow up of HIV-1-infected Korean haemophiliacs, after infection from a common source of virus / Haemophilia 21(1):e1~e11
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