지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.11
- 수록면
- 603 - 608 (6page)
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초록· 키워드
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Background: Korean Red Ginseng (KRG) combined with antiretroviral therapy (ART) has shown benefits in the treatment of HIV-1-infected patients. Current guidelines recommend regimens containing integrase strand transfer inhibitors (INSTIs) as first-line treatment for these patients. The present study assessed the duration of effectiveness of ginseng combination therapy (GCT) in patients receiving INSTIs.
Methods: This study included 58 HIV-1-infected patients previously untreated with monotherapy or two-drug combination therapy. Patients in the GCT (n = 26) group received ART plus KRG for 164 ± 64 months, whereas patients in the control (n = 32) group received ART alone for 128 ± 49 months. Subsequently, patients in these two groups received INSTI for 81 ± 36 months and 68 ± 26 months, respectively.
Results: Before INSTI treatment, only one drug resistance mutation (DRM) was observed in the GCT group, compared with an overall resistance rate of 44.4 % in the control group (P < 0.001). The overall resistance rate was higher in the control than in the GCT group (9.5 % vs. 0.12 %, P < 0.001). During INSTI treatment, the resistance rate in the GCT group remained 0 % for over 5 years, but gradually decreased in the control group from 18.3 % to 13.9 % over 6 years, indicating that the between-group difference in resistance rate gradually decreased during INSTI treatment.
Conclusion: The beneficial effects of KRG were well maintained for more than 20 years, including the INSTI treatment period.
Methods: This study included 58 HIV-1-infected patients previously untreated with monotherapy or two-drug combination therapy. Patients in the GCT (n = 26) group received ART plus KRG for 164 ± 64 months, whereas patients in the control (n = 32) group received ART alone for 128 ± 49 months. Subsequently, patients in these two groups received INSTI for 81 ± 36 months and 68 ± 26 months, respectively.
Results: Before INSTI treatment, only one drug resistance mutation (DRM) was observed in the GCT group, compared with an overall resistance rate of 44.4 % in the control group (P < 0.001). The overall resistance rate was higher in the control than in the GCT group (9.5 % vs. 0.12 %, P < 0.001). During INSTI treatment, the resistance rate in the GCT group remained 0 % for over 5 years, but gradually decreased in the control group from 18.3 % to 13.9 % over 6 years, indicating that the between-group difference in resistance rate gradually decreased during INSTI treatment.
Conclusion: The beneficial effects of KRG were well maintained for more than 20 years, including the INSTI treatment period.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
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