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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 434 - 440 (7page)
이용수
초록· 키워드
오류제보하기
Objective : The purpose of this study was to find an optimal delivery route for clinical trials of intrathecal cell therapy for spinal cord injury in preclinical stage. Methods : We compared in vivo distribution of Cy5.5 fluorescent dye in the spinal cord region at various time points utilizing in vivo optical imaging techniques, which was injected into the lateral ventricle (LV) or cisterna magna (CM) of rats. Results : Although CM locates nearer to the spinal cord than the LV, significantly higher signal of Cy5.5 was detected in the thoracic and lumbar spinal cord region at all time points tested when Cy5.5 was injected into the LV. In the LV injection Cy5.5 signal in the thoracic and lumbar spinal cord was observed within 12 hours after injection, which was maintained until 72 hours after injection. In contrast, Cy5.5 signal was concentrated at the injection site in the CM injection at all time points. Conclusion : These data suggested that the LV might be suitable for preclinical injection route of therapeutics targeting the spinal cord to test their treatment efficacy and biosafety for spinal cord diseases in small animal models.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Bjorklund A / 2000 / Cell replacement therapies for central nervous system disorders / Nat Neurosci 3:537~544
Boulton M / 1999 / Contribution of extracranial lymphatics and arachnoid villi to the clear- ance of a CSF tracer in the rat / Am J Physiol 276:818~823
Bradbury MW / 1965 / A flow of cerebrospinal fluid along the cen- tral canal of the spinal cord of the rabbit and communications between this canal and the sacral subarachnoid space / J Physiol 181:785~800
Chen Y / 2013 / Novel modified method for injection into the cerebrospinal fluid via the cerebellomedullary cistern in mice / Acta Neurobiol Exp (Wars) 73:304~311
Consiglio AR / 2000 / Technique for collecting cerebrospinal fluid in the cisterna magna of non-anesthetized rats / Brain Res Brain Res Protoc 5:109~114
Boulton M / 1999 / Contribution of extracranial lymphatics and arachnoid villi to the clear- ance of a CSF tracer in the rat / Am J Physiol 276:818~823
Bradbury MW / 1965 / A flow of cerebrospinal fluid along the cen- tral canal of the spinal cord of the rabbit and communications between this canal and the sacral subarachnoid space / J Physiol 181:785~800
Chen Y / 2013 / Novel modified method for injection into the cerebrospinal fluid via the cerebellomedullary cistern in mice / Acta Neurobiol Exp (Wars) 73:304~311
Consiglio AR / 2000 / Technique for collecting cerebrospinal fluid in the cisterna magna of non-anesthetized rats / Brain Res Brain Res Protoc 5:109~114
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