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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.7 No.2
- 발행연도
- 2015.1
- 수록면
- 106 - 117 (12page)
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초록· 키워드
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The endoplasmic reticulum (ER) is a specialized organelle that plays a central role in biosynthesis, correct protein folding, and posttranslational modificationsof secretory and membrane proteins. Loss of homeostasis in ER functions triggers the ER stress response, resulting in activation of unfoldedprotein response (UPR), a hallmark of many inflammatory diseases. These pathways have been reported as critical players in the pathogenesis ofvarious pulmonary disorders, including pulmonary fibrosis, lung injury, and chronic airway disorders. More interestingly, ER stress and the relatedsignaling networks are emerging as important modulators of inflammatory and immune responses in the development of allergen-induced bronchialasthma, especially severe asthma.
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등록된 정보가 없습니다.
참고문헌 (100)
참고문헌 신청
Barnes PJ / 2012 / Severe asthma: advances in current management and future therapy / J Allergy Clin Immunol 129:48~59
Wenzel S. / 2012 / Severe asthma: from characteristics to phenotypes to endotypes / Clin Exp Allergy 42:650~658
Kim SR / 2013 / Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation / J Allergy Clin Immunol 132:1397~1408
Bousquet J / 2010 / Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma / J Allergy Clin Immunol 126:926~938
Ammit AJ. / 2013 / Glucocorticoid insensitivity as a source of drug targets for respiratory disease / Curr Opin Pharmacol 13:370~376
Wenzel S. / 2012 / Severe asthma: from characteristics to phenotypes to endotypes / Clin Exp Allergy 42:650~658
Kim SR / 2013 / Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation / J Allergy Clin Immunol 132:1397~1408
Bousquet J / 2010 / Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma / J Allergy Clin Immunol 126:926~938
Ammit AJ. / 2013 / Glucocorticoid insensitivity as a source of drug targets for respiratory disease / Curr Opin Pharmacol 13:370~376
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