지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 271 - 277 (7page)
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초록· 키워드
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Background: Dysmorphic red blood cells (dRBCs) are first-line biomarkers for detecting glomerulonephritis (GN) in patients with hematuria. The UF-1000i system (Sysmex, Kobe, Japan), based on flow cytometry, provides small red blood cell (RBC) values (UF-1000i [UF]-%sRBCs). We evaluated the clinical application of UF-%sRBCs for detecting %dRBCs and GN. Methods: Urine samples of 103 patients (47 with GN; 56 without GN [NGN]) were analyzed using UF-1000i urinalysis, phase-contrast microscopy (PCM), and urine chemistry. Serum creatinine (mg/dL), serum albumin (g/dL), serum protein (mg/dL), urine protein (mg/dL), and urea nitrogen (mg/dL) levels were measured using an automated chemical analyzer. To determine the cut-off level of predicting GN, ROC curve was analyzed. Results: UF-%sRBCs, %dRBCs, urine protein, serum creatinine, and estimated-glomerular filtration rate differed between the GN and NGN groups, with the greatest differences detected for UF-%sRBCs and %dRBCs (P<0.0001). In ROC curve analysis, urine protein had the highest area under the curve (0.828), followed by %dRBCs (0.771) and UF-%sRBCs (0.745). To screen for GN, the best cut-off values of UF-%sRBCs and %dRBCs were >40.5% and >6.7%, respectively. %dRBCs (P=0.0001) and UF-%sRBCs (P=0.0006) differed between the GN and NGN groups in patients with isolated hematuria but without proteinuria. Conclusions: UF-%sRBCs had similar diagnostic power to %dRBCs determined by PCM for identifying patients with GN. UF-%sRBCs may be more useful for diagnosing GN in patients with isolated hematuria. Predicting %dRBCs using UF-1000i will provide information on possible GN in patients presenting with asymptomatic hematuria.
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참고문헌 (28)
참고문헌 신청
채동완 / 2013 / 일차성 사구체신염의 국내발병 현황 / 대한내과학회지 84(1):1~5
Fairley KF / 1982 / Hematuria : a simple method for identifying glomerular bleeding / Kidney Int 21:105~108
De Santo NG / 1987 / Phase contrast microscopy of the urine sediment for the diagnosis of glomerular and nonglomerular bleeding-data in children and adults with normal creatinine clearance / Nephron 45:35~39
Shichiri M / 1988 / Red-cell-volume distribution curves in diagnosis of glomerular and non-glomerular haematuria / Lancet 1:908~911
Shichiri M / 1986 / Use of autoanalyser to examine urinary-red-cell morphology in the diagnosis of glomerular haematuria / Lancet 2:781~782
Fairley KF / 1982 / Hematuria : a simple method for identifying glomerular bleeding / Kidney Int 21:105~108
De Santo NG / 1987 / Phase contrast microscopy of the urine sediment for the diagnosis of glomerular and nonglomerular bleeding-data in children and adults with normal creatinine clearance / Nephron 45:35~39
Shichiri M / 1988 / Red-cell-volume distribution curves in diagnosis of glomerular and non-glomerular haematuria / Lancet 1:908~911
Shichiri M / 1986 / Use of autoanalyser to examine urinary-red-cell morphology in the diagnosis of glomerular haematuria / Lancet 2:781~782
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