Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats?

H. Bengu Cobanoglu; Erkan Vuralkan; Abdullah Arslan; Bengusu Mirasoglu; A. Savas Toklu

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자료유형: 학술저널

저자정보: H. Bengu Cobanoglu Erkan Vuralkan Abdullah Arslan Bengusu Mirasoglu A. Savas Toklu

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제12권 제1호

발행연도: 2019.1

수록면: 66 - 71 (6page)

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Objectives. Cisplatin is an antineoplastic agent, used in the treatment of different types of malignant neoplasms. Side effects such as ototoxicity, nephrotoxicity, and bone marrow toxicity are the main limitations of its clinical use. The aim of the present study was to evaluate the possible effects of hyperbaric oxygen (HBO) therapy as a protective agent in cisplatin-induced ototoxicity in rats. Methods. A total of 30 adult Wistar rats (60 ears) were divided into five equal groups. Group 1 is a control group; group 2 is HBO therapy group; group 3 received 15 mg/kg cisplatin intraperitoneally; group 4 received 15 mg/kg cisplatin intraperitoneally and HBO treatment on the same day; group 5 received 15 mg/kg cisplatin intraperitoneally and HBO treatment 72 hours later. The effect of ototoxicity was measured with distortion product otoacoustic emission testing performed on the days 1, 3, and 7. Results. Groups 4 and 5 that received HBO treatment after cisplatin had better signal-to-noise ratio (SNR) values compared with group 3 that received only cisplatin (P<0.05). Compared with group 5, group 4 (same day HBO treatment) had better SNR values (P<0.05). Conclusion. HBO was found effective for prevention of cisplatin-induced ototoxicity in rats. Our study differs from other studies regarding using a promising treatment, which does not expose subjects to extra stress.

참고문헌 (22)

참고문헌 신청

Fram RJ / 1992 / Cisplatin and platinum analogues : recent advances / Curr Opin Oncol 4(6):1073~1079

Rybak LP / 2009 / Cisplatin ototoxicity and protection : clinical and experimental studies / Tohoku J Exp Med 219(3):177~186

Feghali JG / 2001 / L-n-acetyl-cysteine protection against cisplatin-induced auditory neuronal and hair cell toxicity / Laryngoscope 111(7):1147~1155

Bayindir T / 2014 / The effect of beta glucan on cisplatin ototoxicity / Indian J Otolaryngol Head Neck Surg 66(2):131~134

Rybak LP / 2007 / Mechanisms of cisplatin ototoxicity and progress in otoprotection / Curr Opin Otolaryngol Head Neck Surg 15(5):364~369

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