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논문 기본 정보

자료유형
학술저널
저자정보
Izuchukwu Azuka Okafor (Nnamdi Azikiwe University) Uchenna Somtochukwu Nnamah (Babcock University Teaching Hospital) Jude Nnaka (Nnamdi Azikiwe University)
저널정보
한국생약학회 Natural Product Sciences Natural Product Sciences Vol.26 No.3
발행연도
2020.9
수록면
252 - 258 (7page)
DOI
10.20307/nps.2020.26.3.252

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초록· 키워드

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This study investigated the biochemical and histological changes associated with the co-administration of cisplatin and methanolic extract of Portulaca oleracea (MEPO) in adult Wistar rats. Twenty-four (24) adult female Wistar rats were randomly divided into six (6) groups (A-F) (n = 4). Group A served as the control group for the experiment and received no treatment. Group B was given a single dose of cisplatin and served as the cisplatin control group. Group C and D received 400 mg/kg and 800 mg/kg of MEPO 6 hours after a single dose cisplatin injection respectively. Group E and F received 400 mg/kg and 800 mg/kg of MEPO 6 hours before cisplatin injection. The cisplatin injection was 2 mL/kg given intraperitoneally for all groups. There was a significant increase in the serum levels of ALT, ALP, AST, total bilirubin, and conjugated bilirubin following cisplatin treatment (p = 0.000, 0.000, 0.039, 0.000, 0.004 respectively) with a consequent reversal due to MEPO administration across all treated groups (p = 0.000, 0.000, 0.000, and 0.000) in a dose-dependent fashion. Cisplatin caused the expansion of the red and white pulp in the spleen which was attenuated by MEPO. MEPO demonstrated a protective effect against cisplatin-induced liver and spleen toxicity.

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Abstract
Introduction
Experimental
Results and Discussion
References

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