The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin

Yuksel Toplu; Emrah Sapmaz; Hakan Parlakpinar; Mehmet Kelles; M. Tayyar Kalcioglu; Kevser Tanbek; Ahmet Kizilay

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자료유형: 학술저널

저자정보: Yuksel Toplu Emrah Sapmaz Hakan Parlakpinar Mehmet Kelles M. Tayyar Kalcioglu Kevser Tanbek Ahmet Kizilay

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제9권 제1호

발행연도: 2016.1

수록면: 14 - 20 (7page)

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Objectives. This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. Methods. To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione peroxidase, total oxidant status, total antioxidant status, and oxidative stress index) were evaluated. Thirty-two adult female Wistar albino rats were randomly divided into 4 equal groups; control (K), cisplatin (C), cisplatin plus Dxp (CD), and Dxp (D). In all groups DPOAEs measurements, between 996 and 10,078 Hz as DPOAEs and input/output functions, were performed on days 0, 1th, 5th, and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. Results. In the C group, statistically significant differences were detected at all frequencies between 0 and 5 days and 0 and 12 days measurements (P<0.05). Serum level of oxidant and antioxidant status were detected statistically significantly changed in this group versus K group (P<0.05). Contrary to the C group, in the CD group hearing ability was seen largely preserved at many frequencies and serum levels of all biochemical parameters were shifted toward normal values, similar to the K group. No significant differences were detected in the either D or K group’s measurements. Conclusion. According to these results, Dxp may prevent cisplatin-induced ototoxicity.

#Keywords. Cisplatin #Ototoxicity #Dexpanthenol #Otoacoustic Emissions #Biomarkers

참고문헌 (30)

참고문헌 신청

Williams CJ. / 1979 / Cis-platinum : a new anticancer agent / Br Med J 1(6179):1689~1691

Rabik CA. / 2007 / Molecular mechanisms of resistance and toxicity associated with platinating agents / Cancer Treat Rev 33(1):9~23

Rossof AH. / 1972 / Preliminary clinical experience with cis-diamminedichloroplatinum(II)(NSC 119875, CACP) / Cancer 30(6):1451~1456

JEFF KOPELMAN / 1988 / OTOTOXICITY OF HIGH-DOSE CISPLATIN BY BOLUS ADMINISTRATION IN PATIENTS WITH ADVANCED CANCERS AND NORMAL HEARING / The Laryngoscope 98(8):858~864

Kalcioglu MT. / 2005 / The protective effect of erdosteine against ototoxicity induced by cisplatin in rats / Eur Arch Otorhinolaryngol 262(10):856~863

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