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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.96 No.1
- 발행연도
- 2019.1
- 수록면
- 34 - 40 (7page)
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초록· 키워드
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Purpose: To research the effects of iloprost (IL) and hyperbaric oxygen (HBO) combination treatment on lung injury and on tumor necrosis factor alpha (TNF-α), myeloperoxidase (MPO), malondialdehyde (MDA), and soluble intercellular adhesion molecule-1 (sICAM-1) levels after tissue or organ ischemia-reperfusion, and on ischemia-reperfusion induced lung neutrophil sequestration.
Methods: Forty white New Zealand rabbits were assigned randomly into 5 groups: HBO, IL, HBO+IL, control, and sham groups. TNF-α values were checked before ischemia, in the 1st hour of ischemia and in the 1st and 4th hours of reperfusion, also at the end of reperfusion period, plasma and tissue MPO values, MDA values, and sICAM-1 levels were detected. After sacrifice, the degree of lung injury was determined by histopathological examination.
Results: Compared to the control group all therapy groups showed a drastically meaningful reduction in TNF-α increase in 1, 2, and 4 hours. Plasma and lung MDA, MPO, and sICAM-1 levels were significantly lower in IL, HBO, HBO+IL, and sham groups compared with the control group. IL and/or HBO suppressed MDA and MPO increase in the lung tissue and in plasma. Additionally, histopathological score was significantly lower in HBO, IL, HBO+IL, and sham groups than that of the control group.
Conclusion: Both HBO and IL therapy have a beneficial effect by causing a meaningful reduction in TNF-α production, MPO, MDA, sICAM-1 levels and pulmonary neutrophil sequestration; which play a role, especially, in ischemia reperfusion induced lung damage.
Methods: Forty white New Zealand rabbits were assigned randomly into 5 groups: HBO, IL, HBO+IL, control, and sham groups. TNF-α values were checked before ischemia, in the 1st hour of ischemia and in the 1st and 4th hours of reperfusion, also at the end of reperfusion period, plasma and tissue MPO values, MDA values, and sICAM-1 levels were detected. After sacrifice, the degree of lung injury was determined by histopathological examination.
Results: Compared to the control group all therapy groups showed a drastically meaningful reduction in TNF-α increase in 1, 2, and 4 hours. Plasma and lung MDA, MPO, and sICAM-1 levels were significantly lower in IL, HBO, HBO+IL, and sham groups compared with the control group. IL and/or HBO suppressed MDA and MPO increase in the lung tissue and in plasma. Additionally, histopathological score was significantly lower in HBO, IL, HBO+IL, and sham groups than that of the control group.
Conclusion: Both HBO and IL therapy have a beneficial effect by causing a meaningful reduction in TNF-α production, MPO, MDA, sICAM-1 levels and pulmonary neutrophil sequestration; which play a role, especially, in ischemia reperfusion induced lung damage.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
Bozok S / 2012 / Local angioneogenetic effect of intramuscular interleukin-8 injection / Turkiye Klinikleri J Med Sci 32:1273~1277
Ozgur Firat / 2017 / Omega-3 fatty acids inhibit oxidative stress in a rat model of liver regeneration / 대한외과학회지 93(1):1~10
Goldman G / 1992 / Mast cells and leukotrienes mediate neutrophil sequestration and lung edema after remote ischemia in rodents / Surgery 112:578~586
Ozbek C / 2014 / Surgical stimulation of angiogenesis / Asian Cardiovasc Thorac Ann 22:36~39
Emrecan B / 2008 / Iloprost and pentoxifylline attenuate ischemiareperfusion injury in skeletal muscle in rabbit model / Ulus Travma Acil Cerrahi Derg 14:182~187
Ozgur Firat / 2017 / Omega-3 fatty acids inhibit oxidative stress in a rat model of liver regeneration / 대한외과학회지 93(1):1~10
Goldman G / 1992 / Mast cells and leukotrienes mediate neutrophil sequestration and lung edema after remote ischemia in rodents / Surgery 112:578~586
Ozbek C / 2014 / Surgical stimulation of angiogenesis / Asian Cardiovasc Thorac Ann 22:36~39
Emrecan B / 2008 / Iloprost and pentoxifylline attenuate ischemiareperfusion injury in skeletal muscle in rabbit model / Ulus Travma Acil Cerrahi Derg 14:182~187
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UCI(KEPA) : I410-ECN-0101-2019-514-000442228