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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 83 - 92 (10page)
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Background/Aims: Lysyl oxidase-like 2 (LOXL2), a collagenmodifying enzyme, has been implicated in cancer invasiveness and metastasis. Methods: We evaluated the expression of LOXL2 protein, in addition to carbonic anhydrase IX (CAIX), keratin 19, epithelial cell adhesion molecule, and interleukin 6, in 105 resected hepatocellular carcinomas (HCCs) by immunohistochemistry. Results: LOXL2 positivity was found in 14.3% (15/105) of HCCs, and it was significantly associated with high serum α-fetoprotein levels, poor differentiation, fibrous stroma, portal vein invasion, and advanced TNM stage (p<0.05 for all). Additionally, LOXL2 positivity was significantly associated with CAIX (p=0.005) and stromal interleukin 6 expression (p=0.001). Survival analysis of 99 HCC patients revealed LOXL2 positivity to be a poor prognostic factor; its prognostic impact appeared in progressed HCCs. Furthermore, LOXL2 positivity was shown to be an independent predictor of overall survival and disease-specific survival (p<0.05 for all). Interestingly, co-expression of LOXL2 and CAIX was also an independent predictor for overall survival, disease-specific survival, disease-free survival, and extrahepatic recurrence-free survival (p<0.05 for all). Conclusions: LOXL2 expression represents a subgroup of HCCs with more aggressive behavior and is suggested to be a poor prognostic marker in HCC patients.
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참고문헌 (39)
참고문헌 신청
Ferlay J / 2015 / Cancer incidence and mortality worldwide : sources, methods and major patterns in GLOBOCAN 2012 / Int J Cancer 136:E359~E386
Bruix J / 2011 / American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update / Hepatology 53:1020~1022
Bruix J / 2017 / Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment(RESORCE) : a randomised, double-blind, placebo-controlled, phase 3 trial / Lancet 389:56~66
Yu SJ / 2016 / A concise review of updated guidelines regarding the management of hepatocellular carcinoma around the world : 2010-2016 / Clin Mol Hepatol 22:7~17
Cox TR / 2011 / Remodeling and homeostasis of the extracellular matrix : implications for fibrotic diseases and cancer / Dis Model Mech 4:165~178
Bruix J / 2011 / American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update / Hepatology 53:1020~1022
Bruix J / 2017 / Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment(RESORCE) : a randomised, double-blind, placebo-controlled, phase 3 trial / Lancet 389:56~66
Yu SJ / 2016 / A concise review of updated guidelines regarding the management of hepatocellular carcinoma around the world : 2010-2016 / Clin Mol Hepatol 22:7~17
Cox TR / 2011 / Remodeling and homeostasis of the extracellular matrix : implications for fibrotic diseases and cancer / Dis Model Mech 4:165~178
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